Effects of depression on parameters of cell-mediated immunity in patients with digestive tract cancers

Table 1 SDS 4 grading of depressive manifestations in patients with gut cancers

Item	Factors	-x±s	Grade
			1	2	3	4
X1	I feel downhearted, blue and sad	1.9 ± 0.8	34	50	18	6
X2	Morning is when I feel best	2.6 ± 1.1	18	42	18	30
X3	I have crying spells or feel like it	1.5 ± 0.9	75	14	14	5
X4	I have trouble sleeping through the night	2.1 ± 1.0	42	22	34	10
X5	I eat as much as I used to	2.6 ± 1.0	22	22	46	18
X6	I enjoy looking at, talking to, and being with attractive men/women	2.6 ± 1.1	25	26	26	31
X7	I notice that I am losing weight	2.4 ± 1.0	18	46	22	22
X8	I have trouble with constipation	2.2 ± 1.1	38	30	22	18
X9	My heart beats faster than usual	1.3 ± 0.6	76	16	8	8
X10	I get tired for no reason	2.3 ± 1.1	34	30	22	22
X11	My mind is as clear as it used to be	1.8 ± 0.9	50	30	22	6
X12	I find it easy to do the things I used to do	2.3 ± 0.9	22	42	30	14
X13	I am restless and can’t keep still	1.6 ± 0.9	62	22	18	6
X14	I feel hopeful about the future	2.2 ± 0.9	30	30	42	6
X15	I am more irritable than usual	1.7 ± 1.0	58	26	14	10
X16	I find it easy to make decisions	2.3 ± 1.1	34	26	26	22
X17	I feel that I am useful and needed	1.9 ± 1.0	42	42	10	14
X18	My life is pretty full	1.8 ± 0.8	38	50	14	6
X19	I feel that others would be better off if I were dead	1.8 ± 0.8	70	30	2	6
X20	I still enjoy the things I used to do	2.2 ± 1.0	30	42	18	18

Table 2 Multivariate analysis of contributing factors of depression with step-wise regression

Variable	Unstandardized coefficients (B)	Standardized coefficients (β)	t	P value	Pearson correlation
X1a	4.47	0.36	19 193 329	0.00	0.64
X6a	4.13	0.51	19 076 980	0.00	-0.80
X9a	0.97	0.07	3 266 595.5	0.00	0.65
X13a	1.78	0.15	4 232 747.7	0.00	0.08
Anxietya	6.04E-02	0.06	3 691 620.2	0.00	0.32
CD56a	-2.33	-0.10	-28 074 903	0.00	-0.18

^aP < 0.05 vs nondepression group.

Table 3 Multiple factors between depression and nondepression groups (^-x±s)

Parameters	Depressive	Non-depressive	P
	state	state
Anxiety	49.7 ± 7.5b	45.3 ± 6.9	0.003
Pain	6.5 ± 2.8a	4.6 ± 3.2	0.025
Social support	44.0 ± 6.8	44.6 ± 7.7	0.670
Objective support	11.9 ± 3.0	12.5 ± 3.0	0.360
Subjective support	24.8 ± 3.8	24.5 ± 4.4	0.630
Utilization of support	6.8 ± 2.0a	7.6 ± 2.1	0.043
Cells in peripheral blood
Erythrocyte (1012/L)	3.4 ± 1.2	3.8 ± 1.8	0.460
Lymphocyte (0.00)	0.33 ± 0.09a	0.39 ± 0.87	0.032
Granulocyte (0.00)	0.61 ± 0.12	0.56 ± 0.88	0.240
Monocyte (0.00)	0.04 ± 0.01	0.06 ± 0.05	0.900
Thrombocyte (109/L)	137.5 ± 12.5a	167.7 ± 43.2	0.020
T lymphocyte subsets
CD3 (0.00)	0.53 ± 0.11	0.59 ± 0.11	0.07
CD4 (0.00)	0.27 ± 0.07	0.30 ± 0.11	0.440
CD8 (0.00)	0.32 ± 0.10	0.35 ± 0.10	0.240
Natural killer
CD56 (0.00)	0.26 ± 0.11a	0.29 ± 0.11	0.041

^aP < 0.05,

^bP < 0.01, vs nondepression group.