Ethylene diamine tetraacetic acid induced colonic crypt cell hyperproliferation in rats

Table 1 Characterisation of colorectal tumours

Location	Adenoma	Carcinoma	Total (%)
Caecum	0	1	1 (1.5)
Proximal	2	6	8 (12.1)
Flexure	4	4	8 (12.1)
Distal	12	36	48 (72.7)
Rectum	0	1	1 (1.5)
Total	18	48	66

Table 2 Features of proliferative colonic crypt cells in 6 groups

Group	LC	CPC	TLI	LI 1	LI 2	LI 3	LI 4	P Zone	LIPZ
NP(76)	2.49 ± 0.16	34.45 ± 0.39	7.20 ± 0.45	3.11 ± 0.11	18.78 ± 1.64	13.21 ± 1.50	0.90 ± 0.39	16.75 ± 1.45	59.43 ± 3.39
ND(198)	2.74 ± 0.11	31.45 ± 0.2	8.65 ± 0.34	17.33 ± 1.06	19.54 ± 1.21	6.38 ± 0.76	0.00	21.74 ± 1.07	55.13 ± 2.17
EP(134)	3.71 ± 0.16	37.68 ± 0.27	10.00 ± 0.44	3.36 ± 0.62	19.46 ± 1.41	24.45 ± 1.55	1.67 ± 0.43	21.67 ± 1.13	55.87 ± 2.22
ED(130)	3.58 ± 0.15	32.55 ± 0.21	11.05 ± 0.47	14.76 ± 1.33	23.74 ± 1.66	15.49 ± 1.29	0.9 ± 0.31	27.73 ± 1.46	51.68 ± 2.43
DP(138)	5.7 ± 0.24	49.09 ± 0.65	11.54 ± 0.45	12.87 ± 1.11	21.72 ± 1.41	19.72 ± 1.21	3.47 ± 0.62	35.52 ± 1.58	39.84 ± 1.77
DD(182)	5.67 ± 0.23	42.68 ± 0.53	13.13 ± 0.46	18.23 ± 1.08	24.86 ± 1.31	18.83 ± 1.19	3.43 ± 0.6	39.61 ± 1.32	38.89 ± 1.50
P Values
ND:NP	0.21	0.000	0.019	0.000	0.731	0.000	0.000	0.011	0.3
ED:EP	0.571	0.000	0.107	0.000	0.05	0.000	0.151	0.001	0.203
DD:DP	0.94	0.000	0.017	0.003	0.107	0.604	0.966	0.047	0.682
ND:ED	0.000	0.000	0.000	0.131	0.037	0.000	0.000	0.001	0.3
ND:DD	0.000	0.000	0.000	0.556	0.003	0.000	0.000	0.000	0.000
ED:DD	0.000	0.000	0.002	0.043	0.593	0.062	0.001	0.000	0.000
NP:EP	0.000	0.000	0.000	0.798	0.765	0.000	0.237	0.009	0.365
NP:DP	0.000	0.000	0.000	0.000	0.195	0.001	0.004	0.000	0.000
EP:DP	0.000	0.000	0.016	0.000	0.259	0.017	0.019	0.000	0.000

Values represented as ^-x±S_x, NP(76): Normal proximal, 76 hemi-crypts were counted, ND: Normal distal, EP: EDTA proximal, ED-EDTA distal, DP: DMH proximal, DD: DMH distal, LC: Labelled cells per hemi-crypt, CPC: Cells per hemi-crypt, TLI: Total labelling index, LI1: Labelling index of compartment 1, Pzone: Proliferative zone size, LIPZ: Labelling index of proliferative zone Size.