Expression of estrogen receptor β in human colorectal cancer

Table 1 Expression of ERβ and ERα in CRCs, colonic adenomas and normal colonic mucosa

Group	n	ERα	n	ERβ
		positive (%)		positive (%)
Normal colon mucosa	10	0 (0%)	10	2 (20%)
CRCs	12	3 (25%)	40	23 (57.5%)
Colonic adenoma			10	3 (30%)

Table 2 Clinicopathological characteristics of patitents with CRCs and their association with ERβ expression

Category		n	ERβ	ERβ	P value
			negativity	positivity(%)
Age (years)					> 0.05
	< 50	4	2	2 (50.0)
	≥ 50	36	15	21(58.3)
Sex					> 0.05
	Male	23	9	14 (60.9)
	Female	17	8	9 (52.9)
Lymph node metastasis					> 0.05
	0	18	7	11 (61.1)
	≥ 1	22	10	12 (54.5)
Duke’s type					> 0.05
	A	15	5	10 (66.7)
	B	10	3	7 (70.0)
	C	7	3	4 (57.1)
	D	3	1	2(66.7)
Histological grading					> 0.05
Well -differentiated		15	5	10 (66.7)
Moderately- differentiated		15	7	8 (53.3)
Poorly- differentiated		10	5	5 (50.5)

Table 3 Expression of ERα mRNA in CRC tissue and adjacent normal mucosa tissue

Tissue type	n	+	Positive rate (%)
CRCs	12	3	25%
Normal tissue	12	2	16.6%

Table 4 Expression of ERβ mRNA in CRC tissue and adjacent normal mucosa tissue

Tissue type	n	+	Expression	Level of	P
			rate (%)	ERβmRNA
CRCs	12	10	83.3%	91.15 ± 3.56	> 0.05
Normal tissue	12	11	91.7%	95.38 ± 2.79