Effects of narcotic analgesic drugs on human Oddi’s sphincter motility

Table 1 Manometric data before and after administration of morphine in 40 patients (mean ± SD)

	Before morphine	10 min after morphine	20 min after morphine
	administration (n = 40)	administration (n = 40)	administration (n = 10)
Oddi’s sphincter basal pressure (mmHg)	8.90 ± 9.11	22.23 ± 16.04b	20.51 ± 13.46b
Amplitude of phasic contractions (mmHg)	50.85 ± 36.66	104.97 ± 49.15d	89.04 ± 62.37d
Frequency of phasic contractions (n/min)	7.22 ± 2.89	9.29 ± 1.93f	8.85 ± 2.42f
Common bile duct pressure (mmHg)	4.97 ± 3.87	8.62 ± 7.43h	7.32 ± 5.95h

^bP,

^dP,

^fP,

^hP < 0.01 vs themselves, n represents the number of patients involved in the research.

Table 2 Manometric data before and after administration of pethidine in 10 patients (mean ± SD)

	Before pethidine	10 min after pethidine	19 min after pethidine
	administration (n = 10)	administration (n = 10)	administration 20 (n = 10)
Oddi’s sphincter basal pressure (mmHg)	7.06 ± 5.07	11.24 ± 6.11	6.68 ± 4.32
Amplitude of phasic contractions (mmHg)	78.52 ± 40.23	95.65 ± 45.49	70.35 ± 31.67
Frequency of phasic contractions (n/min)	7.31 ± 1.95	6.49 ± 2.81	7.92 ± 2.07
Common bile duct pressure (mmHg)	4.23 ± 2.83	4.70 ± 3.87	3.91 ± 3.36

n represents the number of patients involved in the research.

Table 3 Manometric data before and after administration of Ap-237 in 10 patients (mean ± SD)

	Before Ap-237	10 min after Ap-237	20 min after Ap-237
	administration (n = 10)	administration (n = 10)	administration (n = 10)
Sphincter of Oddi basal pressure (mmHg)	6.42 ± 5.10	11.33 ± 9.39a	11.34 ± 8.40a
Amplitude of phasic contractions (mmHg)	52.56 ± 30.99	87.03 ± 51.72c	50.06 ± 29.11
Frequency of phasic contractions (n/min)	5.62 ± 1.34	7.72 ± 2.16e	9.28 ± 3.98f
Common bile duct pressure (mmHg)	4.20 ± 3.97	4.82 ± 2.30	3.25 ± 2.30

^aP,

^cP,

^eP < 0.05,

^fP < 0.01 vs themselves, n represents the number of patients involved in the research.

Table 4 Manometric data before and after administration of tramadol in 10 patients (mean ± SD)

	Before tramadol	10 min after tramadol	20 min after tramadol
	administration (n = 10)	administration (n = 10)	administration (n = 10)
Sphincter of Oddi basal pressure (mmHg)	7.01 ± 5.50	2.87 ± 2.78a	6.39 ± 5.37
Amplitude of phasic contractions (mmHg)	63.34 ± 35.29	45.90 ± 27.86c	35.97 ± 24.30d
Frequency of phasic contractions (n/min)	7.24 ± 2.52	8.14 ± 2.54	7.07 ± 3.70
Common bile duct pressure (mmHg)	4.41 ± 2.65	3.97 ± 4.69	4.96 ± 2.82

^aP,

^cP < 0.05,

^dP < 0.01 vs themselves, n represents the number of patients involved in the research.