Tegaserod inhibits noxious rectal distention induced responses and limbic system c-Fos expression in rats with visceral hypersensitivity

Table 1 AWR scores in group H (median, min-max) (n = 8)

	0.4 mL	0.8 mL	1.2 mL
H-saline	2.0 (1-3)	3.5 (3-4)	4.0 (4-4)
H-vehicle	2.0 (0-3)	3.0 (2-4)	4.0 (3-4)
H-Teg0.1	1.0 (0-2)b	2.0 (1-3)a,b	3.0 (3-4)a,b
H-Teg0.3	1.0 (0-1)b	1.5 (0-3)b	3.0 (3-4)a,b
H-Teg1.0	0.5 (0-1)b	1.5 (1-2)b	3.0 (1-3)b

^bP < 0.01 vs H-saline; Difference between H-Teg0.1and H-Teg0.3 was not significant at all volumes;

^aP < 0.05 H-Teg0.1, H-Teg0.3 vs H-Teg1.0.

Table 2 AWR scores in group C (median, min-max, n = 8)

	0.4 mL	0.8 mL	1.2 mL
C-saline	1.0 (0-2)	2.5 (2-3)	3.0 (3-4)
C-Teg1.0	0.0 (0-2)	2.0 (2-2)	3.0 (3-4)
Z value	1.465	2.236	0
P value	0.195	0.105	1.000

The differences between C-saline and C-Teg1.0 were not sig-nificant at all volumes.

Table 3 Number of c-Fos positive neurons in limbic struc-tures in group H (mean ± SD, n = 8)

	ACC Hippocampus HypoTH Amygdala Thalamus Overall
H-saline	72 ± 10	54 ± 13	51 ± 17	44 ± 16	62 ± 19	283 ± 41
H-vehicle	72 ± 10	54 ± 13	49 ± 15	43 ± 15	62 ± 19	281 ± 37
H-Teg0.1	53 ± 14b	48 ± 10	47 ± 13	42 ± 11	50 ± 13	239 ± 31a
H-Teg0.3	40 ± 11b	45 ± 7	41 ± 11a	37 ± 11	45 ± 11a	208 ± 25b
H-Teg1.0	31 ± 8b	36 ± 9b	31 ± 10b	30 ± 8b	34 ± 10b	162 ± 16b
F value	60.583	11.605	8.199	5.362	14.574	61.989
P value	0.000	0.000	0.000	0.000	0.000	0.000

^aP < 0.05,

^bP < 0.01 vs H-saline.

Table 4 Number of c-Fos positive neurons in limbic struc-tures in group C (mean ± SD, n = 8)

	ACC Hippocampus HypoTH Amygdala Thalamus Overall
C-saline	48 ± 8	46 ± 7	36 ± 8	39 ± 7	45 ± 11	214 ± 13
C-Teg1.0	31 ± 7b	36 ± 8b	30 ± 9	33 ± 10	34 ± 7a	164 ± 22b

^aP < 0.05,

^bP < 0.01 vs C-saline.