Effects of Zuogui Wan on neurocyte apoptosis and down-regulation of TGF-&beta;1 expression in nuclei of arcuate hypothalamus of monosodium glutamate -liver regeneration rats

doi:10.3748/wjg.v10.i19.2823

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Oct 1, 2004 (publication date) through Feb 8, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 1, 2004; 10(19): 2823-2826
Published online Oct 1, 2004. doi: 10.3748/wjg.v10.i19.2823

Table 1 Effect of Zuogui Wan on alterations of ARN nuclei in MSG-liver regeneration rat on the postoperative 11^th d (n = 10, mean ± SD)

Group	Shape	Circular	Heteromorphic
Group	factor	degree	index
Normal saline	1.14 ± 0.45	0.88 ± 0.16	3.80 ± 0.8
Model	3.10 ± 1.14^b	0.32 ± 0.17^b	6.24 ± 1.83 ^b
Zuogui Wan	1.68 ± 0.33^d	0.60 ± 0.32^a	4.60 ± 0.74^a

¹t = 5.0572, 7.5856, 3.8633,

^bP < 0.01 vs control (Normal saline); ²t = 2.4436, 2.6273,

^aP < 0.05, ³t = 3.7836,

^dP < 0.01 vs model.

Table 2 Effect of Zuogui Wan on ARN neurocyte apoptosis in MSG-liver regeneration rats (positive cells %, n = 6, mean ± SD)

Group	Postoperative 1^st d	Postoperative 5^th d	Postoperative 11^th d
Normal saline	0.07 ± 0.08	0.08 ± 0.04	0.09 ± 0.03
MSG-rats	2.45 ± 0.32^d	2.32 ± 0.45^d	2.56 ± 0.59^d
Model	2.62 ± 0.72^d	3.32 ± 0.81^a^d	4.23 ± 1.22^a^d
Zuogui Wan	1.62 ± 0.65	1.43 ± 0.75^f	1.12 ± 1.14^f

¹t = 2.6435, 3.0185,

^aP < 0.05 vs MSG-rats; ²t = 17.6741, 12.1451, 10.2414, 8.6222, 9.7860, 8.3097,

^dP < 0.01 vs control (Normal saline); ³t = 4.1938, 4.5624,

^fP < 0.01 vs Model.

Table 3 Effect of Zuogui Wan on TGF-β₁ expression of ARN in MSG-liver regeneration-rats (positive cells %, n = 6, mean ± SD)

Group	Postoperative 1^st d	Postoperative 3^rd d	Postoperative 5^th d	Postoperative 11^th d
Normal saline	10.9 ± 2.7	13.7 ± 2.5	16.8 ± 2.9	12.6 ± 1.6
MSG-rats	12.8 ± 3.1	13.5 ± 2.8	12.3 ± 3.2	14.5 ± 2.9
Model	19.4 ± 2.4^b^d	21.3 ± 2.6^b^d	25.1 ± 2.9^b^d	29.7 ± 2.8^b^d
Zuogui Wan	11.3 ± 2.1^f	12.9 ± 3.2^f	18.8 ± 2.2^f	14.8 ± 1.7^f

¹t = 5.7635, 5.1612, 4.9573, 12.9884,

^bP < 0.01 vs control (Normal saline); ²t = 4.1237, 5.0003, 7.2602, 9.2362,

^dP < 0.01 vs MSG-rats; ³t = 6.2216, 4.9903, 4.2394, 11.1420,

^fP < 0.01 vs Model.

Citation: Li HM, Gao X, Yang ML, Mei JJ, Zhang LT, Qiu XF. Effects of Zuogui Wan on neurocyte apoptosis and down-regulation of TGF-β₁ expression in nuclei of arcuate hypothalamus of monosodium glutamate -liver regeneration rats. World J Gastroenterol 2004; 10(19): 2823-2826
URL: https://www.wjgnet.com/1007-9327/full/v10/i19/2823.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i19.2823