Lymphatic metastasis and nm23H1 genetic instability in Chinese colon cancer patients

Table 1 Comparison of ICAM-1 expression between colon cancer and normal colon (mean ± SD)

Group	Cases	ICAM-1/15HPF
Normal colon	5	11.001 ± 1.58
Colon cancer	32	26.131 ± 9.19b

^aP < 0.05,

^bP < 0.01, vs normal colon group.

Table 2 ICAM-1 expression in colon cancer (mean ± SD)

Dukes stage	Cases	ICAM-1		ICAM-1/15HPF	P Value
		Low-expression	High-expression
A	5	3	2	19.671 ± 5.59
B	15	6	9	23.571 ± 9.65
C	10	3	7	25.591 ± 8.07	< 0.01
D	2	0	2	35.681 ± 2.51
Metastasis	12	3	9	28.091 ± 8.33
No metastasis	20	11	9	22.621 ± 8.99

Table 3 Relationship between clinical pathological parameter and nm23H₁ genetic instability in colon cancer (mean ± SD)

	Cases	MSI (%)	LOH (%)	nm23 (%)	nm23 expression
Histological types	30	8 (26.67)	6 (20.00)	16 (53.33)	40.21 ± 3.29
Tubular adenocarcinoma	25	7 (28.00)	5 (20.00)	15 (60.00)	40.76 ± 2.74
High differentiation	8	2 (25.00)	1 (12.50)	8 (100.00)	41.49 ± 2.01
Intermediate differentiation	13	5 (38.46)	2 (15.38)	6 (46.15)	40.41 ± 1.98
Poor differentiation	4	0 (0.00)	2 (50.00)	1 (25.00)d	40.18 ± 2.17
Mucoid adenocarcinoma	5	1 (20.00)	1 (20.00)	1 (20.00)b	39.53 ± 2.61
TNM stage
Stage I + II	16	7 (43.75)	1 (6.25)	13 (81.25)	42.42 ± 1.08
Stage III + IV	14	1 (7.14)e	5 (35.71)e	3 (21.43)f	39.49 ± 2.57
Dukes stage
A	5	2 (40.00)	0 (0.00)	4 (80.00)	41.32 ± 2.18
B	15	5 (33.33)	3 (20.00)	8 (53.33)	40.69 ± 2.11
C	8	1 (12.50)	1 (12.50)	4 (50.00)	42.32 ± 1.66
D	2	0 (0.00)	2 (100.0)h	0 (0.00)	39.24 ± 2.32

^aP < 0.05,

^bP < 0.01, vs tubular adenocarcinoma group; ^cP < 0.05,

^dP < 0.01 vs high differentiation group;

^eP < 0.05,

^fP < 0.01, vs stage I + II group; ^gP < 0.05,

^hP < 0.01 vs A, B, C groups respectively.

Table 4 Relationship between LOH, MSI and nm23 protein expression (mean ± SD)

Groups	Cases	Expression of nm23 protein (%)	Intensity of nm23 protein
Positive to MSI	8	6/8 (75.00)	39.06 ± 2.14
Negative to MSI	22	10/22 (45.45)	41.14 ± 2.36
Positive to LOH	6	2/6 (33.33)	41.23 ± 2.27
Negative to LOH	24	14/24 (58.33)	39.44 ± 2.52