Clinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirrhosis

Table 1 Serum concentrations of IGF-I, IGF-II and IGFBP-3 in patients with liver cirrhosis and healthy subjects

Category	n	IGF-I (ng/mL)	IGF-II (ng/mL)	IGFBP-3 (ng/mL)
Cirrhosis	44	66 ± 58b	367 ± 193b	12 ± 8b
Control	38	260 ± 74	1094 ± 119	39 ± 7

^bP < 0.001 vs control.

Table 2 Serum concentrations of IGF-I, IGF-II and IGFBP-3 in healthy subjects and patients with different CP scores

Category	n	IGF-I (ng/mL)	P1	IGF-II (ng/mL)	P1	IGFBP-3(ng/mL)	P1
Control	38	260 ± 75	0.001	109 ± 119	0.001	39 ± 7	0.001
CP A	15	119 ± 67	0.001	507 ± 185	0.001	19 ± 8	0.001
CP B	19	45 ± 29	0.001	343 ± 154	0.001	10 ± 5	0.001
CP C	10	27 ± 11	0.001	201 ± 115	0.001	6 ± 3	0.001

P¹ represents the statistical comparison in columns between healthy subjects and patients with different Child Pugh scores (A: scored 5-6; B: scored 7-10; C: scored 11-15). P < 0.001 vs between different groups of the same parameter.