Giorgetti GM, Tursi A, Iani C, Arciprete F, Brandimarte G, Capria A, Fontana L. Assessment of autonomic function in untreated adult coeliac disease. World J Gastroenterol 2004; 10(18): 2715-2718 [PMID: 15309725 DOI: 10.3748/wjg.v10.i18.2715]
Corresponding Author of This Article
Dr. Antonio Tursi, Galleria Pisani, 4, 70031 Andria (BA), Italy. antotursi@tiscali.it
Article-Type of This Article
Brief Reports
Open-Access Policy of This Article
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World J Gastroenterol. Sep 15, 2004; 10(18): 2715-2718 Published online Sep 15, 2004. doi: 10.3748/wjg.v10.i18.2715
Table 1 Demographic, clinical, endoscopic and histological data of the coeliac patients
Patient No.
Sex
Age (yr)
Clinical finding
Endoscopic finding
Histology
1
F
71
Weakness, diarrhoea
Absence of Kerckring’s folds
Marsh IIIc
2
M
58
Diarrhoea, weight loss
Absence of Kerckring’s folds
Marsh IIIb
3
F
31
Aphtous stomatitis, IDA
Reduction of Kerckring’s folds
Marsh IIIb
4
F
31
IDA
“Scalloping” of duodenal folds
Marsh IIIa
5
F
38
Diarrhoea, abdominal pain, weight loss
Reduction of Kerckring’s folds, micronodular mucosa
Marsh IIIc
6
M
33
IDA
Reduction of Kerckring’s folds
Marsh IIIa
7
F
24
IDA, Grave’s disease
Reduction of Kerckring’s folds
Marsh IIIa
8
F
32
IDA, weakness
Reduction of Kerckring’s folds
Marsh IIIa
Table 2 Non-invasive tests in the studied coeliac population
Patient No.
AGA IgA
AGA IgG
EMA
Anti-tTG
Sorbitol H2-BT
1
+
+
+
+
+
2
+
+
+
+
+
3
+
+
+
+
+
4
+
+
-
-
+
5
+
+
+
+
+
6
+
+
-
+
+
7
-
-
+
-
+
8
+
-
-
+
+
Table 3 Evaluation of autonomic function in coeliac patients and control group
Group
LS
VR
DB
△PAS Handgrip
△PAD Handgrip
Coeliac disease
1.22 ± 0.1
1.73 ± 0.38
35.5 ± 16.4
35.7 ± 16.4
24.6 ± 13.2
Control group
1.24 ± 0.19
1.62 ± 0.25
32.5 ± 7.67
55.5 ± 24.2
27.1 ± 11.1
P
NS
NS
NS
NS
NS
Table 4 Evaluation of Heart rate variance in coeliac patients and control group
Group
LF Clino
LF Ortho
HF Clino
HF Ortho
LF/HF Clino
LF/HF Ortho
Coeliac disease
35.9 ± 18.1
73.5 ± 15.3
35.7 ± 18.9
13.21 ± 9.3
1.56 ± 1.85
8.63 ± 6.34
Control group
52.8 ± 21.0
67.1 ± 25.9
31.1 ± 15.6
17.90 ± 12.9
2.35 ± 1.65
6.94 ± 5.5
P
NS
NS
NS
NS
NS
NS
Table 5 Overall results of autonomic tests in coeliac patients
Patient No.
Basal SBP
Basal DBP
Ortho SBP
Ortho DBP
Clino. LF
Ortho. LF
Clino. HF
Ortho.HF
Clino. LF/HF
Ortho. LF/HF
LS
VR
DB
Syst. SH
Diast.SH
Syst. Tilt Test
Diast. Tilt Test
1
127
82
120
82
40.99
61.65
48.00
32.82
0.85
1.88
1.03
1.46
19.2
54
27
-9
7.00
2
130
87
135
87
21.41
60.74
30.09
10.73
0.71
5.66
1.37
1.90
35.9
36
14
-9
5.00
3
130
80
125
80
77.04
92.52
12.89
5.96
5.98
15.52
1.20
1.40
33.3
35
25
19
14.00
4
105
70
105
85
38.26
63.87
20.19
17.85
1.9
3.58
1.20
2.30
40.1
39
36
3
7.00
5
115
80
120
82
31.15
58.43
62.16
16.49
0.5
3.54
1.20
1.40
39.3
48
28
7
14.00
6
120
80
108
75
27.16
87.79
27.33
11.00
0.99
7.98
1.18
1.50
40.2
50
47
2
12.00
7
105
70
115
75
20.30
94.00
61.00
4.79
0.3
19.6
1.30
2.30
44.3
7
6
-7
15.00
8
115
70
80
60
30.93
68.81
23.81
6.06
1.3
11.35
1.30
1.60
31.8
17
14
-10
2.00
Mean
118.38
77.38
113.50
78.25
35.91
73.48
35.68
13.21
1.57
8.64
1.22
1.73
35.51
35.75
24.63
-0.50
9.50
SD
10.20
6.52
16.50
8.51
18.13
15.27
18.88
9.28
1.85
6.34
0.10
0.39
7.74
16.37
13.20
10.23
4.87
Citation: Giorgetti GM, Tursi A, Iani C, Arciprete F, Brandimarte G, Capria A, Fontana L. Assessment of autonomic function in untreated adult coeliac disease. World J Gastroenterol 2004; 10(18): 2715-2718