Gene expression differences of regenerating rat liver in a short interval successive partial hepatectomy

doi:10.3748/wjg.v10.i18.2680

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 15, 2004; 10(18): 2680-2689
Published online Sep 15, 2004. doi: 10.3748/wjg.v10.i18.2680

Table 1 The genes related to liver regeneration altered in 0-36-72-96-144h SISPH (*genes specially altered in SISPH )

No. Gene description	Fold difference	No. Gene description	Fold difference
Unreported genes		^*93 RP24-176A1	2.4
1 AW558171	0.2	94 RP24-347B22	3
2 CG31759-PA	2	95 RP32-28p17	0.4
^*3 CH230-11N5	3.2	96 Adult male liver cDNA	6.4
4 CH230-155H3	0.3	97 DNA segment of Chr 1	3.9
5 CH230-155H3	2.6	98 12 d embryo liver cDNA	2.2
6 CH230-186B23	0.1	99 13 d embryo liver cDNA	0.5
7 CH230-206C20	0.2	Stress response
8 CH230-329A5	0.5	100 Alpha-1 major acute phase protein prepeptide	13.6
9 CH230-372C24	0.1	101 Petaxin	2.6
10 CH230-403C20	0.3	102 Angiotensinogen (Agt)	5.8
^*11 CH230-404C20	2.4	103 Kininogen	8
12 CH230-4L11	4	104 T-kininogen	16.1
13 CH230-7A22	0.1	Glycometabolism
14 Citb585c7	0.3	105 Aldolase B	0.4
^*15 CTD-2328C19	2.5	^*106 C-reactive protein	2.6
^*16 FLJ20356	2.7	107 Glycerol 3-phosphate dehydrogenase (Gpd3)	0.5
17 KIAA1230	2.8	108 Isocitrate dehydrogenase 1 (Idh1)	0.4
18 LOC119392	2.3	^*109 Maize aldolase	0.5
^*19 LOC311304	2	^*110 3-phosphoglycerate dehydrogenase	17.6
^*20 LRRP Aa1-018	2.8	Fatty and stearoyl metabolism
21 LRRP Aa1027	4	111 Malonyl-CoA decarboxylase	0.4
^*22 LRRP Aa1-076	2.6	112 NAD(P) dependent steroid hydrogenase	0.5
^*23 LRRP Aa1-114	2.4	113 P450 cholesterol 7- -hydroxylase (P450 VII)	3
24 LRRP Aa2-020	0.5	114 Prostaglandin D2 synthase 2 (Ptgds2)	2
25 LRRP Aa2-066	0.4	^*115 Retinol dehydrogenase 11	0.5
^*26 LRRP Aa2-111	2.5	116 3-alpha-hydroxysteroid dehydrogenase	0.3
27 LRRP Aa2-174	0.1	Oxidation and reduction response
28 LRRP Aa2-296	3.1	117 Acyl-coA oxidase	0.2
29 LRRP Ab1-021	4.9	118 Alcohol dehydrogenase (ADH)	0.4
30 LRRP Ab1-046	2.9	119 Cytochrom P450 15-beta (Cyp2c12)	0.1
31 LRRP Ab1-108	3	120 Cytochrome b	0.5
32 LRRP Ab1-114	3.4	121 Cytochrome b5 (Cyb5)	0.4
^*33 LRRP Ab1-119	2.1	122 Cytochrome P450	0.2
34 LRRP Ab1-152	0.5	123 Cytochrome P450 (PNCN inducible, Cyp3A1)	0.4
35 LRRP Ab1-216	4.7	124 Cytochrome P450 2E1	0.1
36 LRRP Ab1-331	3	125 Cytochrome P450, 2c39 (Cyp2c39)	0.4
37 LRRP Ab1-334	3.6	^*126 CytochromeP450, 2b19 (Cyp2b15)	0.4
38 LRRP Ab2-001	0.5	127 CytP450 arachidonic acid epoxygenase (cyp 2C23)	0.2
39 LRRP Ab2-001	0.5	128 Flavin-containing monooxygenase 1 (Fmo1)	0.1
40 LRRP Ab2-008	2.1	129 Paraoxonase 1 (Pon1)	0.1
^*41 LRRP Ab2-018	2	^*130 Peroxiredoxin 1 (Prdx1)	0.4
42 LRRP Ab2-034	3	^*131 Plasma selenoprotein P1 (Sepp1)	2.8
^*43 LRRP Ab2-057	0.4	132 Selenium-dependent glutathione peroxidase	0.2
^*44 LRRP Ab2-079	2	Regulation-proteins
^*45 LRRP Ab2-093	2.1	133 II-protein with tetratricopeptide repeats 3	2.3
46 LRRP Ab2-095	4.6	^*134 Glu-Pro dipeptide repeat protein	0.4
47 LRRP Ab2-132	0.4	135 RAKb	0.5
48 LRRP Ab2-143	2	Glycoproteins
49 LRRP Ab2-225	0.3	136 Alpha-1-B glycoprotein (A1bg)	0.1
^*50 LRRP Ab2-255	0.5	137 Fibrinogen, gamma polypeptide (Fgg)	7.2
51 LRRP Ab2-379	3.1	138 Fibronectin 1 (Fn1)	5
^*52 LRRP Ab2-390	2.1	139 Histidine-rich glycoprotein (Hrg)	0.4
53 LRRP Ab2-402	0.4	140 Myelin-associated glycoprotein (L-MAG)	0.3
54 LRRP Ac1-060	2.7	141 TRAM1	2.6
55 LRRP Ac1-163	0.5	142 UDP-glucuronosyltransferase 2B3 (Udpgt)	0.3
56 LRRP Ac1177	0.4	Lipid-proteins
57 LRRP Ac1-233	3.3	143 Apolipoprotein C-I (Apoc1)	0.4
58 LRRP Ac1873	7.1	144 Apolipoprotein C-II	0.3
59 LRRP Ac2-061	3.8	145 Apolipoprotein C-III	0.4
60 LRRP Ac2-125	0.2	146 C57BL/6J	2.2
61 LRRP Ac2-143	4	147 Fatty acid binding protein 1 (Fabp1)	0.2
62 LRRP Ac2-193	3.1	148 Plasma retinol-binding protein (PRBP)	0.5
63 LRRP Ac2-202	4.1	149 Transthyretin-related protein (TTN)	0.2
64 LRRP Ac2-223	2.1	Nucleolar proteins
^*65 LRRP Ac2-256	2.2	150 RNase A family 4	0.4
^*66 LRRP Ac2-282	0.5	Receptors
^*67 LRRP Ac2-300	0.4	151 Cocoa protein	5.5
68 LRRP Ba1-647	3.9	^*152 Golgi SNAP receptor member 1 (Gosr1)	0.4
69 LRRP Bm403207	7.9	153 Nuclear receptor subfamily 0, mem 2 (Nr0b2)	0.2
70 LRRP Cc1-27	0.4	154 Type I interleukin 1 receptor (Il1r1)	6.2
71 LRRP Cc1-8	2.6	Factors
72 LRRP Cc1-9	4.7	155 Angiogenin	0.3
^*73 LRRP Da1-10	2.1	156 Angiopoietin-like 3	0.5
74 LRRP Da1-24	2.8	157 Early growth response factor 1 (Egr1)	2.4
75 LRRP Da1-6	2.9	158 Eukaryotic translation initiation factor 4A1	2.5
^*76 LRRP Da2-19	2.6	159 Insulin-like growth factor I	0.5
^*77 LRRP Da2-35	2.3	160 Neuropeptide Y (Npy)	3.9
^*78 LRRP Da2-4	2.3	Hemoglobins
79 LRRP zbs559	0.4	161 Hemoglobin, alpha 1 (Hba1)	0.3
^*80 MGC38937	2.6	162 Hemoglobin beta chain (Hbb)	0.3
81 RIKEN 1110061A24	3.5	Immunological proteises
82 RIKEN 1300002A08	0.4	163 Achaete-scute complex homolog-like 1 (Ascl1)	0.3
^*83 RIKEN 1500012D08	2.2	164 Complement component 5 (C5)	8.6
^*84 RIKEN 2310045J23	0.5	165 Immunoglobulin C kappa	0.2
85 RIKEN 2810051A14	2	^*166 Fc-gamma receptor class III	5.5
^*86 RIKEN 4930408O21	0.5	167 JE/MCP-1	6.1
87 RP11-281N10	0.5	191 Alpha-1-macroglobulin	3.1
88 RP23-195K1	3.9	192 Contrapsin-like protease inhibitor (CPi-26)	14.1
89 RP23-235O1	0.4	193 Leuserpin-2 (Serpind1)	0.5
90 RP23-35D4	0.5	194 Serine protease inhibitor 1	4.6
91 RP23-417P22	0.4	Phosphorylases
92 RP23-480P21	0.5	^*195 CDK103	2.5
Chaperonins		196 CDK110	0.5
^*168 DnaJ (Hsp40), subfamily B, mem 11 (Dnajb11)	2.6	197 Mss4 protein	3.6
^*169 TCP-1 containing cytosolic chaperonin (CCT)	0.5	^*198 Rho-associated kinase beta (Rock1)	0.5
Cytoskelets		199 Thymidylate kinase (dTMP kinase)	2.8
170 Actin gamma	2.7	Phosphatases
^*171 Actin beta (Actb)	3	200 Pyrophosphatase/phosphodiesterase 1(Enpp1)	4.2
172 Clathrin, heavy polypeptide (Hc) (Cltc)	2.7	201 Phosphatase 1 (GL-subunit)	0.2
173 Karyopherin (importin) alpha 2	0.4	202 Phosphatidylserine-specific phospholipase A1	3
^*174 Mutant beta-actin (beta-actin)	3.4	^*203 Secreted phosphoprotein 1 (Spp1)	2.2
^*175 Ribosomal protein S12 (Rps12)	2.2	^*204 UTP-glucose-1-phosphate	0.4
Marker proteins		Synthases
176 ATP-binding cassette, sub-family C	0.3	^*205 ATPase synthase subunit 6	2.3
^*177 CD164 antigen (Cd164)	0.4	206 Carbamyl phosphate synthetase I	3.3
^*178 CD44 antigen (Cd44)	2.2	^*207 Glutamyl-prolyl-tRNA synthetase (Eprs)	2.6
179 Pregnancy-zone protein (Pzp)	4.7	Transferases
180 Serum amyloid a-5 protein	45.1	208 Carnitine O-octanoyltransferase (Crot)	0.3
181 Subchromosomal transferable fragment 4	0.5	209 Glutathione S-transferase 1 (Mgst1)	0.5
Amino acid enzymes		^*210 Glutathione S-transferase Y(b) subunit	0.4
182 Cytosolic aspartate aminotransferase	5.1	211 Glutathione S-transferase, alpha 1 (Gsta1)	0.1
^*183 Phenylalanine hydroxylase (Pah)	0.4	212 Glutathione S-transferase, type 3 (Yb3) (Gstm3)	0.4
^*184 Tissue-type transglutaminase (Tgm2)	2.8	213 Serine hydroxymethyl transferase 1	2.1
185 2-hydroxyphytanoyl-CoA lyase (Hpcl2)	0.4	214 Sialyltransferase 1 (Siat1)	4.4
Proteolytic enzymes		215 Sulfotransferase K2	0.2
^*186 Alpha/beta hydrolase domain containing protein 1	2.9	216 UDP-glucuronosyltransferase 2, mem 5 (Ugt2b5)	10.4
187 Cathepsin C (Ctsc)	0.4
^*188 Proteasome (macropain subunit, beta type 6 Psmb6)	0.4
Proteinase inhibitors
189 Alpha-1 microglobulin/bikunin (Ambp)	0.4
190 Alpha-2-macroglobulin (A2m)	8.1

Table 2 The comparison of difference of gene expression in SISPH with that after in PH

Gene description	Fold difference		Gene description	Fold difference
Gene description	SISPH	PH	Gene description	SISPH	PH
Unreported genes			Cytochrome P450 (PNCN inducible, Cyp3A1)	0.4	0.2
AW558171	0.2	0.3	Cytochrome P450 2E1	0.1	0.1
CG31759-PA	2	2.9	Cytochrome P450, 2c39 (Cyp2c39)	0.4	0.1
CH230-155H3	0.3	0.3	CytP450 arachidonic acid epoxygenase (cyp 2C23)	0.2	0.2
CH230-155H3	2.6	2.2	Flavin-containing monooxygenase 1 (Fmo1)	0.1	0.1
CH230-186B23	0.1	0.2	Paraoxonase 1 (Pon1)	0.1	0.2
CH230-206C20	0.2	0.3	Selenium-dependent glutathione peroxidase	0.2	0.4
CH230-329A5	0.5	0.3	Regulation-proteins
CH230-372C24	0.1	0.1	II-protein with tetratricopeptide repeats 3	2.3	0.2
CH230-403C20	0.3	0.2	RAKb	0.5	0.2
CH230-4L11	4	4.5	Glycoproteins
CH230-7A22	0.1	0.1	Alpha-1-B glycoprotein (A1bg)	0.1	0.1
Citb585c7	0.3	0.2	Fibrinogen, gamma polypeptide (Fgg)	7.2	7.2
KIAA1230	2.8	2.6	Fibronectin 1 (Fn1)	5	7.2
LOC119392	2.3	2.1	Histidine-rich glycoprotein (Hrg)	0.4	0.1
LRRP Aa1027	4	2.1	Myelin-associated glycoprotein (L-MAG)	0.3	7
LRRP Aa2-020	0.5	0.4	TRAM1	2.6	5.1
LRRP Aa2-066	0.4	0.4	UDP-glucuronosyltransferase 2B3 (Udpgt)	0.3	0.3
LRRP Aa2-174	0.1	0.1	Lipid-proteins
LRRP Aa2-296	3.1	2.1	Apolipoprotein C-I (Apoc1)	0.4	3.3
LRRP Ab1-021	4.9	8.1	Apolipoprotein C-II	0.3	0.3
LRRP Ab1-046	2.9	0.5	Apolipoprotein C-III	0.4	0.5
LRRP Ab1-108	3	2.9	C57BL/6J	2.2	7.3
LRRP Ab1-114	3.4	4.2	Fatty acid binding protein 1 (Fabp1)	0.2	0.3
LRRP Ab1-152	0.5	0.4	Plasma retinol-binding protein (PRBP)	0.5	0.4
LRRP Ab1-216	4.7	6.8	Transthyretin-related protein (TTN)	0.2	0.3
LRRP Ab1-331	3	2.2	Nucleolar proteins
LRRP Ab1-334	3.6	2.7	RNase A family 4	0.4	0.2
LRRP Ab2-001	0.5	0.2	Receptors
LRRP Ab2-001	0.5	0.2	Cocoa protein	5.5	4.6
LRRP Ab2-008	2.1	2.1	Nuclear receptor subfamily 0, mem 2 (Nr0b2)	0.2	0.2
LRRP Ab2-034	3	2.3	Type I interleukin 1 receptor (Il1r1)	6.2	7.8
LRRP Ab2-095	4.6	3.1	Factors
LRRP Ab2-132	0.4	0.1	Angiogenin	0.3	0.2
LRRP Ab2-143	2	3.3	Angiopoietin-like 3	0.5	0.2
LRRP Ab2-225	0.3	0.3	Early growth response factor 1 (Egr1)	2.4	3.6
LRRP Ab2-379	3.1	2.2	Eukaryotic translation initiation factor 4A1	2.5	3.8
LRRP Ab2-402	0.4	0.1	Insulin-like growth factor I	0.5	0.5
LRRP Ac1-060	2.7	0.4,2.3	Neuropeptide Y (Npy)	3.9	18.2
LRRP Ac1-163	0.5	0.4	Hemoglobins
LRRP Ac1177	0.4	0.4, 3.3	Hemoglobin, alpha 1 (Hba1)	0.3	0.3
LRRP Ac1-233	3.3	4.2	Hemoglobin beta chain (Hbb)	0.3	0.3
LRRP Ac1873	7.1	6	Immunological proteises
LRRP Ac2-061	3.8	7.6	Achaete-scute complex homolog-like 1 (Ascl1)	0.3	0.4
LRRP Ac2-125	0.2	0.3	Complement component 5 (C5)	8.6	8.8
LRRP Ac2-143	4	3.3	Immunoglobulin C kappa	0.2	0.2
LRRP Ac2-193	3.1	2.3	JE/MCP-1	6.1	4
LRRP Ac2-202	4.1	2.5	Cytoskelets
LRRP Ac2-223	2.1	2.4	Actin gamma	2.7	4.7
LRRP Ba1-647	3.9	3.2	Clathrin, heavy polypeptide (Hc) (Cltc)	2.7	3.3
LRRP Bm403207	7.9	5.7	Karyopherin (importin) alpha 2	0.4	0.4
LRRP Cc1-27	0.4	2.2	Marker proteins
LRRP Cc1-8	2.6	2.3	ATP-binding cassette, sub-family C	0.3	0.4
LRRP Cc1-9	4.7	2.5	Pregnancy-zone protein (Pzp)	4.7	2.4
LRRP Da1-24	2.8	3.5	Serum amyloid a-5 protein	45.1	90.5
LRRP Da1-6	2.9	2	Subchromosomal transferable fragment 4	0.5	0.3
LRRP zbs559	0.4	3.1	Amino acid enzymes
RIKEN 1110061A24	3.5	3	Cytosolic aspartate aminotransferase	5.1	5.3
RIKEN 1300002A08	0.4	0.3, 2.4	2-hydroxyphytanoyl-CoA lyase (Hpcl2)	0.4	0.4
RIKEN 2810051A14	2	2.7	Proteolytic enzyme
RP11-281N10	0.5	0.3	Cathepsin C (Ctsc)	0.4	0.4
RP23-195K1	3.9	2.4	Proteinase inhibitor
RP23-235O1	0.4	0.2	Alpha-1 microglobulin/bikunin (Ambp)	0.4	2.1
RP23-35D4	0.5	0.4, 2.8	Alpha-2-macroglobulin (A2m)	8.1	21.3
RP23-417P22	0.4	0.1	Alpha-1-macroglobulin	3.1	2
RP23-480P21	0.5	0.4	Contrapsin-like protease inhibitor (CPi-26)	14.1	6.6
RP24-347B22	3	2.2	Leuserpin-2 (Serpind1)	0.5	0.2
RP32-28p17	0.4	0.3	Serine protease inhibitor 1	4.6	5
Adult male liver cDNA	6.4	0.1	Phosphorylases
DNA segment of Chr 1	3.9	6.1	CDK110	0.5	0.5
13 d embryo liver cDNA	0.5	5.9	Mss4 protein	3.6	2.1
Stress response			Thymidylate kinase (dTMP kinase)	2.8	3
Alpha-1 major acute phase protein prepeptide	13.6	6.2	Phosphatases
Petaxin	2.6	2.2	Pyrophosphatase/phosphodiesterase 1(Enpp1)	4.2	6.6
Angiotensinogen (Agt)	5.8	8.4	Phosphatase 1 (GL-subunit)	0.2	0.2
Kininogen	8	3.4	Phosphatidylserine-specific phospholipase A1	3	2.8
T-kininogen	16.1	5.9	Synthase
Glycometabolism			Carbamyl phosphate synthetase I	3.3	2.9
Aldolase B	0.4	0.3	Transferases
Glycerol 3-phosphate dehydrogenase (Gpd3)	0.5	0.4	Carnitine O-octanoyltransferase (Crot)	0.3	0.3
Isocitrate dehydrogenase 1 (Idh1)	0.4	0.3	Glutathione S-transferase 1 (Mgst1)	0.5	0.4
Fatty and stearoyl metabolism			Glutathione S-transferase Y(b) subunit	0.4	0.3
Malonyl-CoA decarboxylase	0.4	0.3	Glutathione S-transferase, alpha 1 (Gsta1)	0.1	0.1
NAD(P) dependent steroid hydrogenase	0.5	0.4	Glutathione S-transferase, type 3 (Yb3) (Gstm3)	0.4	0.3
P450 cholesterol 7- -hydroxylase (P450 VII)	3	0.5, 2.3	Sialyltransferase 1 (Siat1)	4.4	2.6
Prostaglandin D2 synthase 2 (Ptgds2)	2	3	Sulfotransferase K2	0.2	0.3
3-alpha-hydroxysteroid dehydrogenase	0.3	0.2	UDP-glucuronosyltransferase 2, mem 5 (Ugt2b5)	0	0.3
Oxidation and reduction response
Acyl-coA oxidase	0.2	0.4, 2.7
Alcohol dehydrogenase (ADH)	0.4	0.1, 2.4
Cytochrom P450 15-beta (Cyp2c12)	0.1	0.2
Cytochrome b	0.5	0.5
Cytochrome b5 (Cyb5)	0.4	0.2
Cytochrome P450	0.2	0.2

Citation: Xu CS, Zhang AS, Han HP, Yuan JY, Chang CF, Li WQ, Yang KJ, Zhao LF, Li YC, Zhang HY, Rahman S, Zhang JB. Gene expression differences of regenerating rat liver in a short interval successive partial hepatectomy. World J Gastroenterol 2004; 10(18): 2680-2689
URL: https://www.wjgnet.com/1007-9327/full/v10/i18/2680.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i18.2680