Ischemic preconditioning protects liver from hepatectomy under hepatic inflow occlusion for hepatocellular carcinoma patients with cirrhosis

Table 1 clinical characteristics of these two groups

Data	IPC group	control group	P value
Age (yr)	50.4 ± 10.7	49.5 ± 10.3	0.605
Gender			0.684
Male	12	12
Female	2	3
Child’s classification			0.684
Grade A	12	12
Grade B	2	3
Grade C	0	0
OGTT			0.867
P1 type	3	4
P2 type	8	9
L type	4	3
Cirrhosis1			0.316
(+)	13	12
(-)	1	3
Tumor size (cm)	7.1 ± 3.6	7.9 ± 2.9	0.544
Procedures			0.971
Right/left hepatectomy	2	2
Segmentectomy	4	4
Irregular hepatectmoy	8	9
Operation times (min)	191.3 ± 74.9	208.2 ± 45.3	0.485
Ischemic times (min)	18.0 ± 3.6	17.4 ± 2.3	0.602
(Range)	(15-25)	(13-22)
Blood loss (mL)	469.2 ± 292.6	602.0 ± 310.6	0.257

¹Cirrhosis: (+) referrs to macroscopic cirrhosis, which was diagnosed during surgery, (-) referrs to that we could not diagnose cirrhosis during surgery by naked eyes, however, it was diagnosed mild cirrhosis and hepatitis by microscopic pathology. The etiology of cirrhosis was hepatitis B virus infection in our series.

Table 2 Comparison of liver functions between two groups before and after operation

Date	AST (U/L)		ALT (U/L)		TBIL (μmol/L)		ALB (g/L)
	Control	IPC	Control	IPC	Control	IPC	Control	IPC
Preop	64.7 ± 39.2	60.1 ± 55.4	56.7 ± 53.9	54.8 ± 45.0	22.6 ± 13.1	18.9 ± 7.4	41.2 ± 5.6	40.6 ± 3.7
POD1	1856.4 ± 310.9	433.8 ± 143.8b	802.9 ± 280.1	430.9 ± 179.4b	33.1 ± 23.9	26.7 ± 10.3	32.9 ± 4.6	36.2 ± 3.9
POD 3	409.6 ± 197.4	156.7 ± 52.5b	417.3 ± 162.6	200.9 ± 88.6b	49.1 ± 35.4	25.9 ± 9.2a
POD 7	85.3 ± 45.5	56.5 ± 18.9a	130.1 ± 49.0	89.9 ± 42.8a	39.7 ± 29.3	22.8 ± 8.0a

Note: preop = preoperation.

^aP < 0.05, vs control (independent t test):

^bP < 0.01, vs control (independent t test).