Possible causes of central pontine myelinolysis after liver transplantation

Table 1 Clinical characteristics of patients with CNS complications

Patient NO.	Hospital NO.	Age (yr)	Gender	Primary disease	CNS complication	Timing of onset (d)	Timing of survival (d)
1	287206	40	Male	Severe hepatitis	Cerebral hemorrhage	6	11
2	286967	48	Male	Severe hepatitis	CPM	10	15
3	291172	41	Female	Severe hepatitis	Cerebral hemorrhage	8	26
4	299921	54	Male	Severe hepatitis	CPM	6	23
5	306331	53	Female	polycystic liver	Cerebral infarct	4	28
6	312075	51	Male	Hepatic cirrhosis	Cerebral hemorrhage	2	9
7	314112	53	Male	Severe hepatitis	CPM	18	48
8	325113	49	Male	Liver carcinoma	Cerebral hemorrhage	2	2
9	315349	41	Male	Hepatic cirrhosis	CPM	3	20
10	328762	46	Male	Drug liver failure IgA nephropathy	CPM	5	7
11	351480	55	Female	Hepatic cirrhosis	Cerebral hemorrhage	14	56
12	362960	52	Male	Hepatic cirrhosis	Cerebral hemorrhage	3	36
13	363980	46	Male	Severe hepatitis	Cerebral hemorrhage	14	96

Table 2 Comparison of Clinical characteristics in patients with and without CPM

Index	CNS Complications		NO CNS Complication
	CPM	Cerebral hemorrhage/cerebral infarct
Preoperative serum sodium (mmol/L)	130.6 ± 5.54bc	135.9 ± 2.61	137.4 ± 3.83
Preoperative serum magnesium (mg/L)	0.8 ± 0.19	0.9 ± 0.20	1.0 ± 0.21
Preoperative sosm (mOsm/kg H2O)	274.3 ± 33.09	290.2 ± 22.12	292.5 ± 26.05
Change in serum sodium After 48 h (mmol/L)	19.5 ± 6.54bd	10.1 ± 6.43b	4.5 ± 4.34
Postoperative sosm (mOsm/kg H2O)	341.6 ± 14.99bc	317.9 ± 29.76	308.8 ± 16.89
Surgery time (min)	492.0 ± 190.05a	450.0 ± 93.50	399.9 ± 76.07
CsA level (ng/dL)	301.3 ± 9.23b	273.8 ± 28.55a	247.2 ± 35.44

Abbreviations: Sosm: Serum Osmolarity

^aP < 0.05 (0.016, 0.037),

^bP < 0.01 (0.000, 0.001) compared with no CNS complications;

^cP < 0.05 (0.017, 0.02),

^dP < 0.01 (0.000) compared with cerebral hemorrhage/infarct.