Copyright
©The Author(s) 2004.
World J Gastroenterol. Aug 15, 2004; 10(16): 2383-2390
Published online Aug 15, 2004. doi: 10.3748/wjg.v10.i16.2383
Published online Aug 15, 2004. doi: 10.3748/wjg.v10.i16.2383
Table 1 Laboratory biochemistry in β -thalassemia major patients with gallstones, biliary sludge and gallstone-free
Gallstones | Sludge | Gallstone/ sludge-free | P | |
No. of subjects | 7 | 6 | 10 | |
Total bilirubin (mg/dL) | 2.3 ± 0.4 | 1.4 ± 0.4 | 1.8 ± 0.3 | NS |
AST (U/L) | 50.9 ± 11.5 | 32.8 ± 12.5 | 44.9 ± 9.7 | NS |
ALT (U/L) | 76.7 ± 17.7 | 42.7 ± 19.1 | 59.8 ± 14.8 | NS |
Ferritin (mg/dL) | 1 922 ± 445 | 1 165 ± 481 | 1 900 ± 372 | NS |
Hb (g/dL) | 9.3 ± 0.1 | 9.5 ± 0.2 | 9.5 ± 0.1 | NS |
Iron (mg/dL) | 186.8 ± 16.8 | 189.6 ± 8.4 | 156.5 ± 16.8 | NS |
Total proteins (g/dL) | 7.8 ± 0.2 | 7.9 ± 0.2 | 7.4 ± 0.2 | NS |
GGT (U/L) | 34.4 ± 5.6 | 18.3 ± 6.0 | 19.4 ± 4.7 | NS |
Alk. Phosphatase (U/L) | 1.15 ± 0.2 | 0.98 ± 0.2 | 0.9 ± 0.2 | NS |
LDH (U/L) | 331.3 ± 46.7 | 293.7 ± 36.7 | 310.7 ± 28.4 | NS |
Cholesterol (mg/dL) | 98.3 ± 10.2 | 129.4 ± 12.1 | 96.9 ± 9.0 | NS |
Tryglicerides (mg/dL) | 114.9 ± 23.5 | 71.6 ± 27.9 | 84.4 ± 22.0 | NS |
Table 2 Dyspeptic symptoms, bowel habits and gastrointestinal motility indices (gallbladder, stomach, small bowel) in β -thalas-semia major patients with or without gallstone/sludge and in controls
Gallstones | Sludge | GS/sludge-free | Controls | P | |
No. of subjects | 7 | 6 | 10 | 70 | |
Dyspepsia (Buckley score) | 5.0 ± 1.0 | 6.8 ± 2.2 | 7.8 ± 2.5a | 4.9 ± 0.2 | 0.046 |
Bowel habits (Bristol score) | 3.5 ± 0.21 | 3.4 ± 0.6 | 3.8 ± 0.2 | 3.5 ± 0.07 | NS |
Stomach | |||||
Fasting antral area (cm2) | 2.8 ± 0.2 | 2.9 ± 0.2 | 3.4 ± 0.3 | 3.2 ± 0.1 | NS |
Postprandial maximal area (cm2) | 10.4 ± 0.2 | 10.7 ± 0.5 | 10.9 ± 0.4 | 11.5 ± 0.2 | NS |
Postprandial minimal area (%) | 0.9 ± 0.5 | 0.3 ± 0.3 | 0.4 ± 0.7 | 2.1 ± 0.4 | NS |
Postprandial minimal (cm2) | 2.9 ± 0.2 | 3.0 ± 0.2 | 3.3 ± 0.2 | 3.4 ± 0.1 | NS |
Half-emptying time (min) | 28 ± 2 | 31 ± 2 | 28 ± 2 | 27 ± 1 | NS |
Gallbladder | 30.1 ± 3.8a | 42.9 ± 10.3a | 40.6 ± 8.9a | 20.3 ± 0.7 | 0.000001 |
Fasting volume (mL) | 4.4 ± 0.9 | 10.0 ± 2.7ac | 9.1 ± 2.3ac | 5.1 ± 0.3 | 0.00030 |
Postprandial residual volume (mL) | 14.7 ± 1.6a | 23.0 ± 2.7 | 22.6 ± 2.4 | 24.6 ± 1.0 | 0.023 |
Postprandial residual volume (%) | 21 ± 1 | 27 ± 5a | 26 ± 2a | 20 ± 1 | 0.009 |
Half-emptying time (min) | 30.1 ± 3.8a | 42.9 ± 10.3a | 40.6 ± 8.9a | 20.3 ± 0.7 | 0.000001 |
Small bowel | |||||
Orocecal transit Time (min) | 128.6 ± 13.4a | 30.0 ± 15.0a | 136.0 ± 13.6a | 99.7 ± 2.3 | 0.000002 |
Table 3 Prior gallbladder motility indices in β -thalassemia ma-jor patients according to ultrasonographic appearance of the gallbladder during 8-12 mo follow-up
- Citation: Portincasa P, Moschetta A, Berardino M, Ciaula AD, Vacca M, Baldassarre G, Pietrapertosa A, Cammarota R, Tannoia N, Palasciano G. Impaired gallbladder motility and delayed orocecal transit contribute to pigment gallstone and biliary sludge formation in β -thalassemia major adults. World J Gastroenterol 2004; 10(16): 2383-2390
- URL: https://www.wjgnet.com/1007-9327/full/v10/i16/2383.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i16.2383