Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor κB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma

Table 1 Characteristics of all patients

Case No	Stage	H pylori infection	Case No	Stage	H pylori infection
1	II	+	21	III	+
2	IV	+	22	IV	+
3	IV	+	23	IV	+
4	III	+	24	IV	+
5	IV	+	25	IV	-
6	IV	+	26	IV	+
7	IV	+	27	I	+
8	III	-	28	I	-
9	III	+	29	IV	-
10	III	+	30	II	+
11	IV	+	31	IV	+
12	IV	-	32	IV	+
13	IV	-	33	IV	+
14	IV	+	34	III	+
15	IV	+	35	II	+
16	II	+	36	III	+
17	III	-	37	IV	-
18	IV	+	38	IV	+
19	IV	+	39	IV	+
20	II	-	40	II	-

Table 2 8-oHdG, iNOS, NFκB, Mel-1 and IAP Concentrations in cancer and adjacent non-cancer tissues

	Cancertissue	H pylori (+)	Stages I & II	Stages III & IV
8-OHdG	↑a	↑a	-	↑a
iNOS	↑b	↑b	-	↑b
NF-κB	↑a	↑a	-	↑a
MEKK1	-	-	-	-
Caspase 3	-	-	↓b	-
Bcl-2	-	-	↓b	-
Mcl-1	↑a	↑a	-	↑a
IAP	↑a	↑a	-	↑a

↑: increase, ↓: decrease, -: no significant change, ^aP < 0.05, ^bP < 0.01 compared with control, by one sample t-test and independent t-test, respectively.