Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells

Table 1 Effect of Tan II-A on cell cycle distribution and apoptosis in SMMC-7721

Group	Cell cycle distribution (%)			PI %	AI %
	G0/G1	S	G2/M
Control	71.3 ± 2.3	9.8 ± 0.6	18.9 ± 1.6	28.7 ± 2.6	4.9 ± 0.4
Tan II-A	77.8 ± 3.8b	7.2 ± 0.5b	15.0 ± 1.2b	22.2 ± 2.2b	16.9 ± 1.2

χ² test.

^bP < 0.01 vs control group.

Table 2 Effect of Tan II-A on apoptosis associated gene expres-sion of SMMC-7721

Group	Positive rate of protein expression (%)
	fas	p53	bax	bcl-2	c-myc
Control	19.7 ± 0.5	21.4 ± 1.6	20.2 ± 1.6	27.9 ± 2.4	23.8 ± 1.8
Tan II A	28.4 ± 2.5b	39.1 ± 3.1b	31.5 ± 2.7b	16.3 ± 1.3b	14.6 ± 1.1b

χ² test.

^bP < 0.01 vs control group.