SEN virus does not affect treatment response in hepatitis C virus coinfected patients but SEN virus response depends on SEN virus DNA concentration

Table 1 Characteristics of SENV positive and SENV negative patients

	SENV positive (n = 21)	SENV negative (n = 74)	P value
Median age (yr)	42 ± 12	42 ± 12	0.991
Male, m (%)	13 (62%)	46 (62%)	1.002
Median baseline ALT (IU/L )	81 ± 109	69 ± 60	0.561
Pretreated, n (%)	3 (14%)	10 (14%)	1.002
Hepatitis C genotype, n (%)
1, 4	16 (76%)	51 (69%)	0.602
2, 3	5 (24%)	21 (28%)	0.792
Undetermined	0 (0%)	2 (3%)
PEG-IFN	11 (52%)	35 (47%)	0.812
Sustained HCV response to therapy	11 (52%)	37 (50%)	1.002

¹Mann-Whitney test;

²Fisher´s exact test.

Table 2 Clinical, biochemical and viral characteristics in rela-tion to HCV response to combination therapy

	Sustained response (n = 48)	No sustained response (n = 47)	P value
Male, n (%)	30 (63%)	29 (62%)	0.341
Age (yr )	39 ± 11	45 ± 11	< 0.012
ALT	70 ± 78	74 ± 68	0.542
HCV genotype, n (%)
1 or 4	30 (63%)	37 (79%)
2 or 3	16 (33%)	10 (21%)	0.161
Undetermined	2 (4%)
SEN positive, n (%)	10 (21%)	11 (23%)	0.811
SENV H-DNA	393 ± 297	523 ± 452	0.482
(copies/mL)

¹Fisher´s exact test;

²Mann-Whitney test.

Table 3 Clinical and virological characteristics of patients coinfected with HCV and SENV

No	Age (yr)	SEX	ALT (U/L)	HCV	SENV	SENV H	HCV	SEN V
				genotype	genotype	copies/mL	response	response
1	60	M	62	1	H	218	Yes	Yes
2	47	F	26	1	D/H	74	No	Yes
3	41	F	41	1	D	-	Yes	No
4	31	M	26	1	H	208	Yes	Yes
5	59	F	62	1	H	1304	No	No
6	47	F	169	2	H	1184	No	No
7	31	M	26	1	H	484	Yes	No
8	28	M	32	1	H	308	Yes	Yes
9	63	M	168	1	H	310	No	No
10	59	F	121	4	H	338	No	Yes
11	35	F	42	2	H	38	Yes	Yes
12	36	M	43	1	H	532	No	Yes
13	41	M	24	1	H	848	Yes	Yes
14	41	M	180	1	D	-	Yes	Yes
15	32	F	513	3	H	224	Yes	Yes
16	44	F	36	3	D	-	Yes	Yes
17	28	M	28	2	H	814	Yes	Yes
18	42	M	40	1	H	74	No	Yes
19	37	M	32	4	H	230	No	Yes
20	62	F	41	1	H	662	No	Yes

Table 4 Clinical and virological parameter of SENV re-sponse to combination therapy in 20 HCV/SENV-coinfected patients

	SENV response (15)	SENV nonresponse (5)	P
Age (yr, mean)	41 ± 12	48 ± 13	0.231
Male	10 (63%)	3 (60%)	1.02
ALT	85 ± 61	80 ± 123	0.351
SENV H-DNA (copies/mL)	371 ± 276 (n = 13)	820 ± 497 (n = 4)	0.051

¹Mann-Withney test;

²Fisher´s exact test.