Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma

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Jun 15, 2004 (publication date) through Oct 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 2004; 10(12): 1815-1818
Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1815

Table 1 Correlation between methylation of Syk promoter region and clinicopathologic factors (n)

Factor	Frequency of Syk promoter region methylation	P
Gender
Male	14/38
Female	7/23	0.26
Tumor size
< 3cm	8/26
3	13/35	0.61
Depth of invasion
Mucosa and submucosa	2/9
Muscle and subserosa	7/29
Serosa	12/23	0.075
Lymph node metastasis
Present	17/31
Absent	4/30	0.0016
Stage
I-II	6/25
III-IV	15/36	0.24
Tumor location
Lower third	6/15
Middle third	11/35
Upper third	4/11	0.83

Citation: Wang S, Ding YB, Chen GY, Xia JG, Wu ZY. Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma. World J Gastroenterol 2004; 10(12): 1815-1818
URL: https://www.wjgnet.com/1007-9327/full/v10/i12/1815.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i12.1815