Management of nonfunctioning islet cell tumors

Table 1 Clinical presentations

Symptoms	Patients(n=43)	(%)
Abdominal pain	24	55.8
Nausea and/or vomiting	14	32.6
Fatigue	11	25.6
Abdominal mass	10	23.3
Back pain	9	21.0
Jaundice	8	18.6
Weight loss	5	11.6
No symptoms	3	7.0
Acut abdomen	1	2.3

Table 2 Location of the tumors

Location	Malignant (n = 28)	Benign (n = 15)
Head	13	8
Tail	8	2
Body	2	4
Body+Tail	4	1
Multiple	1	0

Table 3 Nature operative procedures

Nature	Malignant (n = 28)	(%)	Benign (n = 15)	(%)
Curative resection	17	61.0	13	87.0
Palliative resection	8	28.6	1	6.7
Palliative bypass	2	5.1	1	6.7
Biopsy only	1	3.6	0	0

Table 4 Primary operative procedures

Procedure	Malignant (n = 28)	(%)	Benign (n = 15)	(%)
Pancreatoduodenectomy	8	28.5	2	13.3
Pylorus-preserving pancreatoduodenectomy	0	0	1	6.7
Distal pancreatectomy + splenectomy	7	25.0	5	33.3
Subtotal pancreatectomy + splenectomy	4	14.3	2	13.3
Distal pancreatectomy	2	7.1	0	0
Enucleation	1	3.6	4	26.7
Double bypass	1	3.6	0	0
Biliary bypass	3	10.7	1	6.7
Gastric bypass	1	3.6	0	0
Biopsy only	1	3.6	0	0

Table 5 Survival of patients with NFICC

Patients	n	5-yr	10-yr	Median
		survival (%)	survival (%)	survival (mo)
ALL cases	28	58.05	29.03	60 ± 4.35
Male	5	40.00	20.00	45 ± 21.92
Female	23	63.49	31.75	120 ± 44.05
≤ 30 yr	14	54.17	36.11	120 ± 64.02
> 30 yr	14	57.69	0	101
D1 ≤ 10 cm	18	67.57	49.05	101
D1 > 10 cm	10	36.00	0	60 ± 21.75
PD2	7	71.43	35.71	101 ± 56.73
STRP3	1 4	72.00	36.00	120 ± 44.94
PO4	7	0	0	24 ± 3.19

¹Diameter of the cancer,

²Pancreatoduodenectomy,

³Subtotal resection of pancreas,

⁴palliative operation.

Table 6 Multivariate Cox regression analysis

Factors	Standard Error	Degree of freedom	P value
Sex	2.190	1	0.679
Age	1.292	1	0.821
Location	35.889	1	0.917
Operation	1.528	1	0.007
Tumor Size	117.237	1	0.903
Radial/palliative	117.261	1	0.884