Copyright
©The Author(s) 2004.
World J Gastroenterol. May 15, 2004; 10(10): 1504-1507
Published online May 15, 2004. doi: 10.3748/wjg.v10.i10.1504
Published online May 15, 2004. doi: 10.3748/wjg.v10.i10.1504
Table 1 Causes of biliary strictures (n = 126)
| Benign | n | % | Malignant | n | % |
| Choledocholithiasis | 12 | 22 | Cholangiocarcinoma | 31 | 43 |
| Mirizzi syndrome | 7 | 13 | Pancreatic head CA | 23 | 32 |
| Postcholecystectomy | 6 | 11 | Ampullary CA | 5 | 7 |
| Sclerosing cholangitis | 3 | 5.5 | Gallbladder CA | 5 | 7 |
| Choledochal cyst | 2 | 3.7 | Metastatic CA | 4 | 5.5 |
| Chronic pancreatitis | 1 | 1.9 | Hepatocellular CA | 2 | 2.7 |
| Juxtapapillary | 1 | 1.9 | Lymphoma | 2 | 2.7 |
| diverticulum | |||||
| Non-specified | 22 | 40.7 | |||
| TOTAL | 54 | TOTAL | 72 |
Table 2 Demographic data of patients with biliary strictures (n = 126)
| Benign | Malignant | P value | |
| Number of patients | 54 (%) | 72 (%) | |
| Mean age | 53 ± 18 | 62.4 ± 11.7 | 0.0006 |
| Males | 25 (46) | 41 (56.9) | 0.2255 |
| Females | 29 (54) | 31 (43.1) | 0.2255 |
| Sites of biliary stricture | |||
| Proximal | 27 (50) | 20 (27.7) | 0.0107 |
| Middle | 22 (41) | 17 (23.6) | 0.0394 |
| Distal | 5 (9) | 35 (48.6) | < 0.001 |
Table 3 Presenting symptoms of patients with biliary stric-tures (n = 126)
| Benign n = 54 (%) | Malignant n = 72 (%) | P value | |
| Jaundice | 44 (81) | 61 (84.7) | 0.5884 |
| RUQ pain | 27 (50) | 38 (52.8) | 0.7561 |
| Weight loss | 4 (7) | 11 (15.3) | 0.1326 |
| Fever | 3 (5) | 7 (9.7) | 0.3066 |
| Anorexia | 4 (7) | 7 (9.7) | 0.5843 |
Table 4 Laboratory data of patients with biliary strictures (n = 126)
| Benign n = 54 | Malignant n = 72 | P value | |
| Total bilirubin (μmol/L) | 142.6 ± 98.4 | 184.61 ± 120.8 | 0.0389 |
| Direct bilirubin (μmol/L) | 102.4 ± 95.3 | 138.10 ± 98.5 | 0.0433 |
| Alkaline phosphatase (IU/L) | 108.5 ± 48.5 | 145.50 ± 57.5 | 0.0002 |
| GGT (IU/L) | 397.0 ± 496.5 | 436.50 ± 325.1 | 0.591 |
| ALT (IU/L) | 52.7 ± 38.3 | 66.94 ± 35.6 | 0.0339 |
| AST (IU/L) | 76.5 ± 43.2 | 107.80 ± 45.7 | 0.0002 |
Table 5 Receiver operator characteristic (ROC) test results in predicting malignant biliary strictures
| Parameter | Cut-off value | Sensitivity (%) | Specificity (%) | +LR | -LR |
| Total bilirubin (μmol/L) | 84 | 98.6 | 59.3 | 2.42 | 0.02 |
| Direct bilirubin (μmol/L) | 63 | 91.7 | 61.1 | 2.36 | 0.14 |
| Alkaline | 136 | 59.7 | 83.3 | 3.58 | 0.48 |
| phosphatase (IU/L) | |||||
| GGT (IU/L) | 246 | 80.6 | 53.7 | 1.74 | 0.36 |
| ALT (IU/L) | 68 | 45.8 | 81.5 | 2.47 | 0.66 |
| AST (IU/L) | 85 | 76.4 | 74.1 | 2.95 | 0.32 |
- Citation: Al-Mofleh IA, Aljebreen AM, Al-Amri SM, Al-Rashed RS, Al-Faleh FZ, Al-Freihi HM, Abdo AA, Isnani AC. Biochemical and radiological predictors of malignant biliary strictures. World J Gastroenterol 2004; 10(10): 1504-1507
- URL: https://www.wjgnet.com/1007-9327/full/v10/i10/1504.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i10.1504