Expression of Span-21 and Ypan-21 in gastric cancer and subtypes of intestinal metaplasia

Table 1 Expression of Span-1 and Ypan-1 in different types of gastric cancer

Histological type	n	Span-1 (%)	Ypan-1 (%)
WMDAC	41	35 (85.4)	29 (70.7)
PDAC	37	12 (48.6)b	17 (45.9)
SRCC	15	12 (80.0)	13 (86.7)
MAC	17	15 (88.2)	13 (76.5)

^bP < 0.01, PDAC vs WMDAC, SRCC or MAC. WMDAC: Well and moderately differentiated adenocarcinoma; PDAC: Poorly differentiated adenocarcinoma; SRCC: Signet-ring cell carcinoma; MAC: Mucinous adenocarcinoma.

Table 2 Expression of Span-1 and Ypan-1 in dysplasia and intestinal metaplasia

Lesions		n	Span-1 (%)	Ypan-1 (%)
I	Dysplasia	32	20 (62.5)	21 (65.6)
II	IM with GC	79	44 (55.7)	41 (51.9)
III	IM with CAG	173	103 (59.5)	101 (58.4)
IV	IM with GU	31	17 (54.8)	17 (54.8)
V	IM with CSG	28	7 (26.5)b	11 (39.3)a

^bP < 0.01, Span-1, Lesion V vs I, II or III;

^aP < 0.05, Ypan-1, Lesion V vs I. GC: Gastric cancer; IM: Intestinal metaplasia; CAG: Chronic atrophic gastritis; GU: Gastric ulcer; CSG: Chronic superficial gastritis.

Table 3 Expression of Span-1 and Ypan-1 in different types of intestinal metaplasia

Type	n	Span-1 (%)	Ypan-1 (%)
Type I	156	66 (42.3)	71 (45.5)
Type II	82	42 (51.2)	41 (50.0)
Type III	105	83 (79.0)b	79 (75.2)b

^bP < 0.01, Span-1 and Ypan-1, Type III vs Type I or II.

Table 4 Expression of Span-1 and Ypan-1 in different grades of intestinal metaplasia

Grade	n	Span-1 (%)	Ypan-1 (%)
Mild	107	41 (38.3)	45 (42.1)b
Moderate	152	87 (57.2)a	88 (57.9)
Severe	84	63 (75.0)	58 (69.0)

^aP < 0.05, Span-1, moderate vs mild or severe;

^bP < 0.01, Ypan-1, mild vs moderate or severe.

Table 5 Expression of Span-1 and Ypan-1 in normal adult and fetal Gastrointestinal mucosa

Mucosa	n	Span-1 (%)	Ypan-1 (%)
Normal adult
Gastric	20	0	0
Intestinal	15	0	1 (6.7)
Colonic	20	0	4 (20.0)
Fetal
Gastric	10	0	0
Intestinal	10	6 (60.0)	9 (90.0)
Colonic	10	0	2 (20.0)