An investigation of SP, VIP, cGRP levels in gastric antrum of experiment spleen deficiency rats

doi:10.3748/wjg.v2.iSuppl1.37

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Sep 15, 1996 (publication date) through Mar 7, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 1996; 2(Suppl1): 37-37
Published online Sep 15, 1996. doi: 10.3748/wjg.v2.iSuppl1.37

An investigation of SP, VIP, cGRP levels in gastric antrum of experiment spleen deficiency rats

Su-Mei Liu, Rui-Yao Qu, Wei Wang, Wen-Hong Zeng, Bai-Lin Qu, Xiu-Qin Wang, Xiao-Bei Zeng, Hong-Wei Shang

Su-Mei Liu, Rui-Yao Qu, Wei Wang, Wen-Hong Zeng, Bai-Lin Qu, Department of Physiology, Capital University of Medical Sciences, Beijing 100054, China

Xiu-Qin Wang, Xiao-Bei Zeng, Hong-Wei Shang, Department of Histology and Embryology, Capital University of Medical Sciences, Beijing 100054, China

Author contributions: All authors contributed equally to the work.

Received: October 12, 1995
Revised: April 22, 1996
Accepted: May 13, 1996
Published online: September 15, 1996

Abstract

AIM: Substance P (SP), vasoactive intestinal peptide (VIP) and calcitonin gene related peptide (cGRP) levels in all layers of gastric antrum in experimental spleen deficiency (SD) rats were measured by radioimmunassays (RIA) in order to study the potential role of some gastrointestinal peptides in the gastrointestinal motility disorders presented in SD.

METHODS: 24 adult Wistar rats were used and divided into 4 groups, i.e. control group (n = 5), experimental SD group (n = 8), spontaneous recovery group (n = 5) and therapeutic group (n = 5) treated with Chinese herbs (sijunzi tang). A small piece of gastric antrum tissue including all layers was removed and processed for RIA.

RESULTS: The results showed that: The ir-SP, ir-VIP, ir-CGRP levels in gastric antrum of SD rats were significantly lower than that of control. In spontaneous recovery cases, ir-SP level was still less than that of control, P < 0.05 while ir-VIP, ir-cGRP levels recovered (vs control, P < 0.05). ir-VIP, ir-cGRP were improved to the levels of co ntrol group (P > 0.05).

CONCLUSION: Our study suggested that there were significantly changes of SP, VIP, cGRP levels in gastric antrum of SD rats. These changes may be closely related to the gastrointestinal motility disorders presented in SD. The Chinese herbs (Sijunzi tang) currently used have partially therapeutic effect. However it still needs to be studied whether this Chinese medicine could completely improve the SD syndrome.

Key Words: Substance P; Vasoactive intestinal peptide; calcitonin gene related peptide levels; Gastric antrum; Experiment spleen deficiency

Citation: Liu SM, Qu RY, Wang W, Zeng WH, Qu BL, Wang XQ, Zeng XB, Shang HW. An investigation of SP, VIP, cGRP levels in gastric antrum of experiment spleen deficiency rats. World J Gastroenterol 1996; 2(Suppl1): 37-37
URL: https://www.wjgnet.com/1007-9327/full/v2/iSuppl1/37.htm
DOI: https://dx.doi.org/10.3748/wjg.v2.iSuppl1.37

Footnotes

Original title: China National Journal of New Gastroenterology (1995-1997) renamed World Journal of Gastroenterology (1998-).

E- Editor: Liu WX