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Letter to the Editor Open Access
©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. May 21, 2008; 14(19): 3105-3105
Published online May 21, 2008. doi: 10.3748/wjg.14.3105
Perivascular epithelioid cell tumour of the liver
Unne Stenram, Department of Pathology, Lund University, Lund SE-22185, Sweden
Author contribution: Stenram U contributed all to this paper.
Correspondence to: Unne Stenram, Department of Pathology, University Hospital, Lund SE-22185, Sweden. unne.stenram@med.lu.se
Telephone: +46-46-173407
Fax: +46-46-143307
Received: October 8, 2007
Revised: April 5, 2008
Published online: May 21, 2008

Abstract

Perivascular epithelioid cell tumour is not uncommon in the liver but seldom malignant.

Key Words: Perivascular epithelioid cell tumour; Liver



TO THE EDITOR

I read with great interest the work by Fang, Zhou, Jin and Hu, dealing with perivascular epithelioid cell tumour (angiomyolipoma) of the liver[1]. It is right that, in mesenchymal tissues, the tumour is common in the uterus. The most frequent localization generally is, however, in the kidney[23]. In the liver, 110 cases had been described by 1999[3].

It is true that the malignant cases are much fewer.

Our interest in this entity was arisen, when we scrutinized a hepatic tumour, described from our department as an oncocytic adenoma[4]. However, the tumour later turned out to be positive for the melanocytic marker HMB-45 and is in fact a perivascular epithelioid cell tumour. The journal refused to publish the revised diagnosis!

References
1.  Fang SH, Zhou LN, Jin M, Hu JB. Perivascular epithelioid cell tumor of the liver: a report of two cases and review of the literature. World J Gastroenterol. 2007;13:5537-5539.  [PubMed]  [DOI]
2.  Hornick JL, Fletcher CD. PEComa: what do we know so far? Histopathology. 2006;48:75-82.  [PubMed]  [DOI]
3.  Tryggvason G, Blondal S, Goldin R, Albrechtsen J, Bjornsson J, Jonasson J. Epithelioid angiomyolipoma of the liver: case report and review of the literature. APMIS. 2004;112:612-616.  [PubMed]  [DOI]
4.  el Hag IA, Ekberg H, Tranberg KG, Lundstedt C, Johansson S, Sassner P, Hagerstrand I. Oncocytic liver tumours and arterial dilatation. Case report. Eur J Surg. 1994;160:55-59.  [PubMed]  [DOI]
Footnotes

Peer reviewer: David Adams, Professor, Liver Research Laboratories, Institute for Biomedical Research, Queen Elizabeth Hospital, University of Birmingham, Birmingham B15 2TT, United Kingdom