Letters To The Editor Open Access
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World J Gastroenterol. Jan 28, 2007; 13(4): 651-651
Published online Jan 28, 2007. doi: 10.3748/wjg.v13.i4.651
Treatment regimen design in clinical radiotherapy for hepatoma
Jian-She Yang, Life Science School of Northwest Normal University, Lanzhou 730070, Gansu Province, China
Jian-She Yang, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Jian-She Yang, PhD, Associate Professor, Northwest Normal University, No.967 Anning Road (East), Anning District, Lanzhou 730070, Gansu Province, China. yangjs@impcas.ac.cn
Telephone: +86-21-59554727 Fax: +86-931-7971564
Received: October 27, 2006
Revised: December 3, 2006
Accepted: December 14, 2006
Published online: January 28, 2007

Abstract

TO THE EDITOR

Recently, the paper by Wang et al[1] published in World Journal of Gastroenterology has given rise to great interest of many researchers. It is well known that hepatoma is one of the lethal diseases with a high incidence in the world, especially in Asia. Radiotherapy is the main treatment modality of hepatoma in clinical practice. Unfortunately, intrinsic radiosensitivity of cancer cells is not fully understood, though a large number of papers on it are now available. Yang and colleagues[2] have developed the premature chromosome condensation technique for clinical radiotherapy of hepatoma. A precise and quick measurement of cell radiosensitivity can detect the high-risk results after exposure to a large dose.

Premature chromosome condensation technique can quickly and precisely detect radiation-induced chromosome damage[3-5]. Chromatid breaks are regarded as a good radiodosimetry, which highly correlates with cell survival and radiosensitivity[6]. However, they are not a negative value as described by Wang et al[1]. I recommend her to further measure them in order to perfect this promising approach.

Footnotes

S- Editor Liu Y L- Editor Wang XL E- Editor Ma WH

References
1.  Wang ZZ, Li WJ, Zhang H, Yang JS, Qiu R, Wang X. Comparison of clonog. enic assay with premature chromosome condensation assay in prediction of human cell radiosensitivity. World J Gastroenterol. 2006;12:2601-2605.  [PubMed]  [DOI]  [Cited in This Article: ]
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