Effect of matrine on Kupffer cell activation in cold ischemia reperfusion injury of rat liver

Figure 1 Chemical structure of (+)-Matrine

Figure 2 Effect of matrine on ALT plasma level after 5-hour cold preservation and reperfusion in rat orthotopic liver transplantation. (n = 6 at each time); b: very significantly differ-ent from control (P < 0.01); c: significantly different from the small-dose treated group (P < 0.05); d: very significantly differ-ent from the small-dose treated group (P < 0.01).

Figure 3 Effect of matrine on plasma HA level after 5-hour cold preservation and reperfusion in rat orthotopic liver transplantation. (n = 6 at each time); b: very significantly differ-ent from control (P < 0.01); d: very significantly different from the small-dose treated group (P < 0.01).

Figure 4 Effect of matrine on endotoxin plasma level after 5-hour cold preservation and reperfusion in rat orthotopic liver transplantation. (n = 6 at each time) b: very significantly differ-ent from control (P < 0.01)

Figure 5 Effect of matrine on TNF cytotoxicity after 5-hour cold preservation and reperfusion in rat orthotopic liver transplantation. (n = 6 at each time).

Figure 6 Effect of matrine on hepatic TNF-α level after 5-hour cold preservation and reperfusion in rat orthotopic liver transplantation. (n = 6 at each time)

Figure 7 Histological appearance of the rat liver at 4 h after reperfusion A: control group; B: a small-dose treated group. (HE staining paraffin-embedded 5 μm thick-sections. × 200)

Figure 8 Electron microscopic pictures of rat liver in control group 4 h after reperfusion. (Original magnifications: × 6000)