Anti-inflammatory effect of cholecystokinin and its signal transduction mechanism in endotoxic shock rat

Figure 1 CCK-8 alleviated pulmonary (upper, × 100) and spleen (lower, × 200) structural injury 6 h after LPS administration. A. Control group; B. LPS group; C. CCK-8 + LPS group; D. CCK-8 group. Plate depicts a representative field from one of three rats.

Figure 2 Effect of CCK-8 on LPS-induced increase of phagocytic capacity of Candida albicans by alveolar macrophages isolated 2 h after LPS administration. ^aP < 0.05 vs Control, ^bP < 0.01 vs LPS.

Figure 3 p38 MAPK (A) was activated by LPS and enhanced by CCK-8 in rat lung (left) or spleen (right) using Western blotting. Degradation of IκB-α in lung and spleen following LPS administration was observed and pre-administration of CCK-8 could reduce its degradation. These figures are representative of three different experiments.1. Normal control, 2 LPS (8 mg•kg⁻¹), 3. CCK-8 (40 μg•kg⁻¹) + LPS, 4. CCK-8.