Pharmacokinetics of traditional Chinese syndrome and recipe: a hypothesis and its verification (I)

Figure 1 HPLC chromatography of A: TMP (methaqualone, IS) added to rat serum; B: FA (coumarin, IS) in rabbit serum 1: FA (t_R:3. 82 min), 2: coumarin (t_R: 7.68 min); C: serum sample after oral administ ration of LWandSM extracts in rats; D: sample serum after oral administration of TMPP. 1: TMP (t_R: 3.992 min). 2: coumarin (t_R: 6.233 min). 3: methanol (t_R: 1.017); 4, 5: impurities in serum (t_R: 1.725 min and t_R: 2.467 min); 6, 7: unknown components (t_R: 3.000 min and t_R: 3.201 min)

Figure 2 TMP concentration-time curve in serum after oral administration of TMPP in healthy rat (n = 6), RMSDS (n = 6) and RMSDS treated by SJZD (n = 6), ^aP < 0. 05 vs; ^bP < 0.01 vs healthy rat.

Figure 3 FA concentration-time curve in serum after intravenous administration of sodium ferulate (5 mg/kg). ^aP < 0.05; ^bP < 0.01 vs healthy rabbit.

Figure 4 TMP concentration-time curve in serum after oral administration of boiled water extract to rats. ^aP < 0.05 vs LW extract.