Effects of combined use of diallyl disulfide and N-acetyl-cysteine on acetaminophen hepatotoxicity in β-naphthoflavone pretreated mice

Figure 1 Effect of DADS and NAC on liver GSH level.

Figure 2 DADS and NAC on plasma ALT levels.

Figure 3 Effects of DADS and NAC on BNF-induced CYP-1A1/1A2 activity (O-ER activity). 1. No BNF (constitutive activity) 2. BNF (induced activity) 3. BNF + DADS 4. BNF + NAC 5. BNF + DADS + NAC Enzyme activity assayed in absence (A) and presence (B) of anti-CYP 1A1/1A2 antibodies.

Figure 4 Direct effect of DADS and NAC on P450 1A1/1A2 activity.