Glasgow prognostic score as a predictor of decompensation in patients with primary biliary cholangitis

Figure 1 Flowchart of study subject selection. AIH: Autoimmune hepatitis; PBC: Primary biliary cholangitis; UDCA: Ursodeoxycholic acid.

Figure 2 Kaplan-Meier analysis of the association between Glasgow prognostic score and decompensation risk. Cumulative incidence of decompensation (%). A: Glasgow prognostic score (GPS): Orange = GPS 0, blue = GPS 1, green = GPS 2; B: Modified GPS (mGPS): Orange = mGPS 0, blue = mGPS 1, green = mGPS 2; C: High-sensitivity mGPS (hs-mGPS): Orange = hs-mGPS 0, blue = hs-mGPS 1, green = hs-mGPS 2. GPS: Glasgow prognostic score; mGPS: Modified Glasgow prognostic score; hs-mGPS: High-sensitivity modified Glasgow prognostic score.

Figure 3 Predictive performance of the Glasgow prognostic score, modified Glasgow prognostic score, high-sensitivity modified Glasgow prognostic score, Paris I, Paris II, Mayo, United Kingdom-primary biliary cholangitis, and GLOBE scores for decompensation events. GPS: Glasgow prognostic score; hs-mGPS: High-sensitivity modified Glasgow prognostic score; mGPS: Modified Glasgow prognostic score; PBC: Primary biliary cholangitis; UK-PBC: United Kingdom-primary biliary cholangitis.

Figure 4 Statistical comparison of the performance of the Glasgow prognostic score, modified Glasgow prognostic score, high-sensitivity modified Glasgow prognostic score, Paris I, Paris II, Mayo, United Kingdom-primary biliary cholangitis, and GLOBE scores for predicting decompensation events. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. DeLong’s test for pairwise area under the curve comparison. Comparisons without asterisks indicate P > 0.05 by DeLong’s test. GPS: Glasgow prognostic score; hs-mGPS: High-sensitivity modified Glasgow prognostic score; mGPS: Modified Glasgow prognostic score; PBC: Primary biliary cholangitis; UK-PBC: United Kingdom-primary biliary cholangitis.

Figure 5 Analysis of the association between Glasgow prognostic score, modified Glasgow prognostic score, high-sensitivity modified Glasgow prognostic score and decompensation was performed in subgroups based on model for end-stage liver disease score. GPS: Glasgow prognostic score; hs-mGPS: High-sensitivity modified Glasgow prognostic score; MELD: Model for end-stage liver disease; mGPS: Modified Glasgow prognostic score.