Role of postoperative endoscopy after peroral endoscopic myotomy: Evidence from a large cohort study

Figure 1 Forest plots of univariable and multivariable logistic regression analyses for intraoperative adverse events and pathological findings on postoperative endoscopy. A and B: Odds ratios with 95% confidence intervals are shown for univariable models; C and D: Odds ratios with 95% confidence intervals are shown for multivariable models. Achalasia type was modeled as a categorical variable with three levels (types I-III), with type I serving as the reference category. Continuous variables are expressed per unit increase or per interquartile range, as indicated. Procedural experience thresholds, with the number of peroral endoscopic myotomy procedures performed at our center by a surgeon as markers of cumulative surgeon’s experience. iAE: Intraoperative adverse events; OR: Odds ratio; IQR: Interquartile range; GLM: Generalized linear model; BMI: Body mass index; myotomy rate: Time required to perform the myotomy, expressed as minutes per centimeter (minute/cm); prev. myotomy: Previous myotomy; OP Nr.: Cumulative number of procedures performed; prev. dilatation: Previous dilatation; prev. endoscopy: Any kind of previous endoscopic intervention (botox injection and/or dilatation) before the first peroral endoscopic myotomy at our center; TTS: Time to surgery (period from initial disease onset/initial diagnosis to first peroral endoscopic myotomy at our center); prev. botox: Previous botox injection; ASA: American Society of Anesthesiologists; LRT: Likelihood ratio test; ES: Eckardt score; NS: Not significant.

Figure 2 Number needed to screen for the detection of pathological findings on postoperative endoscopy. Bar charts depict the number needed to screen (NNS) required to detect pathological findings in patient subgroups. A-D: Subgroup-specific NNS estimates for unselected study population (A), patients with intraoperative adverse events (iAEs) (B), patients without iAEs (C), and patients who did not undergo programmed endoscopic evaluation (D); E: Summary of NNS shown in panels A-D. Within all panels, individual bars are labeled groups A-J and correspond to the categories described below each subfigure. All estimates are presented descriptively, and no formal statistical comparisons between categories were performed. NNS: Number needed to screen; iAE: Intraoperative adverse events; EGD: Esophagogastroduodenosocopy.