Novel regulatory network of the TGF-β/ZEB1/LMO7 axis in colorectal cancer metastasis

doi:10.3748/wjg.119058

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 7, 2026; 32(37): 119058
Published online Oct 7, 2026. doi: 10.3748/wjg.119058

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Figure 1 The transforming growth factor-β/zinc finger E-box binding homeobox 1/LIM domain only protein 7 signaling axis orchestrates the epithelial-mesenchymal transition in colorectal cancer. Extracellular transforming growth factor-β from the tumor microenvironment binds to its receptors on the cancer cell membrane, activating the canonical SMAD signaling pathway. This activation leads to the upregulated expression of the transcription factor zinc finger E-box binding homeobox 1 within the nucleus. Zinc finger E-box binding homeobox 1 directly binds to the promoter region of the LIM domain only protein 7 gene and drives its transcriptional expression, thereby promoting tumor metastasis. TGFβ: Transforming growth factor β; TGFβRI: Transforming growth factor beta receptor 1; TGFβRII: Transforming growth factor beta receptor 2; LMO7: LIM domain only protein 7; ZEB1: Zinc finger E-box binding homeobox 1; EMT: Epithelial-mesenchymal transition.

Citation: Yao X, Hu XY, Tan HF, Tang JF, Zhang R, Zhou CF. Novel regulatory network of the TGF-β/ZEB1/LMO7 axis in colorectal cancer metastasis. World J Gastroenterol 2026; 32(37): 119058
URL: https://www.wjgnet.com/1007-9327/full/v32/i37/119058.htm
DOI: https://dx.doi.org/10.3748/wjg.119058

Yao X, Hu XY, Tan HF, Tang JF, Zhang R, Zhou CF. Novel regulatory network of the TGF-β/ZEB1/LMO7 axis in colorectal cancer metastasis. World J Gastroenterol 2026; 32(37): 119058 [DOI: 10.3748/wjg.119058]

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