Non-exonuclease domain POLE mutations and their biological significance in colorectal cancer

doi:10.3748/wjg.118014

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2026; 32(32): 118014
Published online Aug 28, 2026. doi: 10.3748/wjg.118014

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Figure 1 Co-mutational patterns on non-exonuclease domain mutations colorectal cancer. EDM: Exonuclease domain mutation; CRC: Colorectal cancer.

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Figure 2 Integrated biomarker framework for colorectal cancer treatment decisions. CRC: Colorectal cancer; dMMR: Deficient mismatch repair; EDM: Exonuclease domain mutation; pMMR: Proficient mismatch repair; MMR: Mismatch repair; MSI: Microsatellite instability; MSI-H: High levels of microsatellite instability; MSS: Microsatellite stable; TMB: Tumor mutational burden.

Citation: Kyrochristou I, Kyrochristou GD, Lianos GD. Non-exonuclease domain POLE mutations and their biological significance in colorectal cancer. World J Gastroenterol 2026; 32(32): 118014
URL: https://www.wjgnet.com/1007-9327/full/v32/i32/118014.htm
DOI: https://dx.doi.org/10.3748/wjg.118014

Kyrochristou I, Kyrochristou GD, Lianos GD. Non-exonuclease domain POLE mutations and their biological significance in colorectal cancer. World J Gastroenterol 2026; 32(32): 118014 [DOI: 10.3748/wjg.118014]

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