Transmembrane emp24 domain-containing protein 4 regulates nuclear factor kappa-B/snail signaling to influence hepatocellular carcinoma cell behaviors

doi:10.3748/wjg.118822

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 28, 2026; 32(24): 118822
Published online Jun 28, 2026. doi: 10.3748/wjg.118822

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Figure 1 Transmembrane emp24 domain-containing protein 4 messenger RNA expression in LO2 and SMMC-7721 cells. Compared with LO2 cells, ^aP < 0.05. TMED4: Transmembrane emp24 domain-containing protein 4; mRNA: Messenger RNA.

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Figure 2 Effect of transmembrane emp24 domain-containing protein 4 overexpression plasmid transfection on transmembrane emp24 domain-containing protein 4 messenger RNA expression in SMMC-7721 cells. Compared with the control group, ^aP < 0.05. TMED4: Transmembrane emp24 domain-containing protein 4; mRNA: Messenger RNA.

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Figure 3 Effect of transmembrane emp24 domain-containing protein 4 overexpression on the proliferation of SMMC-7721 cells. Compared with the control group, ^aP < 0.05. TMED4: Transmembrane emp24 domain-containing protein 4; OD: Optical density.

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Figure 4 Effect of transmembrane emp24 domain-containing protein 4 overexpression on the migration and invasion of SMMC-7721 cells. Compared with the control group, P < 0.05. TMED4: Transmembrane emp24 domain-containing protein 4.

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Figure 5 Effect of transmembrane emp24 domain-containing protein 4 overexpression on the protein expression of transmembrane emp24 domain-containing protein 4, snail, and nuclear factor kappa-B p65 in SMMC-7721 cells. Compared with the control group, ^aP < 0.05. Lane 1: Control group; Lane 2: Transmembrane emp24 domain-containing protein 4 overexpression group; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; TMED4: Transmembrane emp24 domain-containing protein 4; NF-κB: Nuclear factor kappa-B.

Citation: Hao FT, Geng ZM. Transmembrane emp24 domain-containing protein 4 regulates nuclear factor kappa-B/snail signaling to influence hepatocellular carcinoma cell behaviors. World J Gastroenterol 2026; 32(24): 118822
URL: https://www.wjgnet.com/1007-9327/full/v32/i24/118822.htm
DOI: https://dx.doi.org/10.3748/wjg.118822

Hao FT, Geng ZM. Transmembrane emp24 domain-containing protein 4 regulates nuclear factor kappa-B/snail signaling to influence hepatocellular carcinoma cell behaviors. World J Gastroenterol 2026; 32(24): 118822 [DOI: 10.3748/wjg.118822]

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