Tumor laterality in primary intestinal diffuse large B-cell lymphoma: A prognostic leap or an anatomical mirage?

Figure 1 Conceptual framework illustrating the transition from the current evidence for tumor laterality in primary intestinal diffuse large B-cell lymphoma (left) to the proposed future research roadmap (right). The “anatomical mirage” reflects methodological limitations, modest clinical effect size, and lack of mechanistic insight, whereas the “prognostic leap” emphasizes biologically annotated cohorts, cutting-edge spatial and microbial technologies, and translation into personalized therapeutic strategies. This framework highlights the necessity of moving beyond retrospective anatomical correlation toward integrated multi-dimensional biology. PI-DLBCL: Primary intestinal diffuse large B-cell lymphoma; SEER: Surveillance, Epidemiology, and End Results; IPI: International Prognostic Index; LDH: Lactate Dehydrogenase; HR: Hazard Ratio.