Plasma apolipoprotein A2 isoforms predict the development of pancreatic fistula following distal pancreatectomy

Figure 1 Flowchart of study participant selection. ApoA2-AT: Apolipoprotein A2-AT/AT.

Figure 2 Comparison of plasma apolipoprotein A2 isoforms levels between the postoperative pancreatic fistula group and the non-postoperative pancreatic fistula group, and receiver operating characteristic curve analysis to predict postoperative pancreatic fistula. A: Distribution of apolipoprotein A2-AT/AT (apoA2-AT) levels. The median preoperative apoA2-AT values in the postoperative pancreatic fistula (POPF) (n = 30) and non-POPF (n = 21) groups were 59.2 μg/mL and 30.2 μg/mL, respectively (Wilcoxon rank-sum test, P < 0.001); B: Distribution of apoA2-ATQ levels. The median preoperative apoA2-ATQ values in the POPF and non-POPF groups were 91.2 μg/mL and 126.0 μg/mL, respectively (P = 0.266); C: Distribution of apoA2-ATQ/AT levels. The median preoperative apoA2-ATQ/AT values in the POPF and non-POPF groups were 72.0 μg/mL and 62.4 μg/mL, respectively (P = 0.135); D: Receiver operating characteristic curve analysis for predicting POPF based on the three apoA2-isoforms levels. The area under the curve values for apoA2-AT/AT, apoA2-ATQ/ATQ, and apoA2-ATQ/AT to predict POPF were 0.802, 0.594, and 0.625, respectively. ApoA2-AT: Apolipoprotein A2-AT/AT; POPF: Postoperative pancreatic fistula; ApoA2-ATQ: Apolipoprotein A2-ATQ/ATQ; ROC: Receiver operating characteristic; AUC: Area under the curve.