Modified Hu-Lian-Bi-Guan decoction for wound healing in complex anal fistula: A randomized controlled trial

doi:10.3748/wjg.v32.i11.117149

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Mar 21, 2026 (publication date) through Apr 4, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 21, 2026; 32(11): 117149
Published online Mar 21, 2026. doi: 10.3748/wjg.v32.i11.117149

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Figure 1 Kaplan-Meier analysis of time to wound healing in the modified Hu-Lian-Bi-Guan decoction group compared with the control group. mHLBGD: Modified Hu-Lian-Bi-Guan decoction.

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Figure 2 Histopathological results of postoperative wound tissue in two groups (hematoxylin-eosin staining). Low-power (left, scale bar = 20 μm) and high-power (right, scale bar = 10 μm). mHLBGD: Modified Hu-Lian-Bi-Guan decoction.

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Figure 3 Comparison of mRNA expression of inflammatory cytokines, TGF-β/Smad signaling molecules, and epithelial-mesenchymal transition markers in two groups. ^aP < 0.05. Pre: Pre-treatment; Post: Post-treatment; mHLBGD: Modified Hu-Lian-Bi-Guan decoction; N-cad: N-cadherin; VIM: Vimentin; E-cad: E-cadherin.

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Figure 4 Comparison of protein expression levels of inflammatory cytokines, TGF-β/Smad signaling molecules, and epithelial-mesenchymal transition markers in two groups. A: Relative protein expression levels of each group; B: Western blot analysis of wound tissue protein expression. ^aP < 0.05. Pre: Pre-treatment; Post: Post-treatment; Con: Control; mHLBGD: Modified Hu-Lian-Bi-Guan decoction; N-cad: N-cadherin; VIM: Vimentin; E-cad: E-cadherin.

Citation: Yang HW, Li TT, Song XB, Lai LX, Yu Q, Ma HF, Wang Y, Zhang XC, Chen XY, Zhang SX, Li JN. Modified Hu-Lian-Bi-Guan decoction for wound healing in complex anal fistula: A randomized controlled trial. World J Gastroenterol 2026; 32(11): 117149
URL: https://www.wjgnet.com/1007-9327/full/v32/i11/117149.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i11.117149