Gastric metastasis of small cell lung carcinoma: Three case reports and review of literature

Figure 1 Chest computed tomography image. A: A mass of approximately 5.0 cm × 4.0 cm in the left hilar region of the lung (case 1); B: A mass of approximately 7 cm × 3 cm in the left lower lobe of the lung (case 2).

Figure 2 Gastroscopy and endoscopic ultrasound findings. A and B: Gastroscopy suggested submucosal lesions with two central depressions and ulcer formation in the body and fundus of the stomach, respectively; C: Endoscopic ultrasound (EUS) suggested submucosal hypoechoic lesion of the gastric body; D: EUS suggested hypoechoic lesions of the portal vein (A-D; case 1); E: Gastroscopy suggested a submucosal lesion with ulcer formation was seen in the greater curvature of the stomach; F: EUS showed a submucosal hypoechoic lesion in the greater curvature of the stomach (E and F; case 2); G: A 4 mm × 5 mm mucosal lesion with a depressed tip (G; case 3).

Figure 3 Immunohistochemical examination of the lesion of case 1. A: Positive expression of CD56; B: Positive expression of thyroid transcription factor; C: Positive expression of chromogranin A; D: Positive expression of synaptophysin; E: Immunohistochemical staining displaying Ki-67 (70%); A-D: Magnification, × 200.

Figure 4 Immunohistochemical examination of the lesion of case 2. A: Positive expression of CD56; B: Positive expression of chromogranin A; C: Positive expression of synaptophysin; D: Immunohistochemical staining displaying Ki-67 (70%); E: Positive expression of thyroid transcription factor; A-D: Magnification, × 200.

Figure 5 Immunohistochemical examination of the lesion of case 3. A: Positive expression of CD56; B: Positive expression of chromogranin A; C: Positive expression of thyroid transcription factor; D: Immunohistochemical staining displaying Ki-67 (80%) (magnification, × 200).