Excess non-COVID-19-related mortality among inflammatory bowel disease decedents during the COVID-19 pandemic

Figure 1 Observed coronavirus disease 2019-related, non-coronavirus disease 2019-related, and predicted age-standardized mortality rate trends among inflammatory bowel disease, ulcerative colitis, and Crohn’s disease decedents from 2006 to 2021. A-C: Trends in age-standardized mortality rate (ASMR) per 100000 persons are shown among inflammatory bowel disease (A), ulcerative colitis (B), and Crohn’s disease decedents (C). Error bars represent the 95% confidence intervals for predicted ASMR. ASMR: Age-standardized mortality rate; COVID-19: Coronavirus disease 2019.

Figure 2 Observed coronavirus disease 2019-related, non-coronavirus disease 2019-related, and predicted age-standardized mortality rate trends among Crohn’s disease and ulcerative colitis decedents stratified by age from 2006 to 2021. A-D: Trends in age-standardized mortality rate (ASMR) per 100000 persons are shown among Crohn’s disease (CD) decedents age 25-64 (A), CD decedents age ≥ 65 (B), ulcerative colitis (UC) decedents age 25-64 (C), and UC decedents age ≥ 65 (D). Error bars represent the 95% confidence intervals for predicted ASMR. ASMR: Age-standardized mortality rate; COVID-19: Coronavirus disease 2019.

Figure 3 Observed coronavirus disease 2019-related, non-coronavirus disease 2019-related, and predicted age-standardized mortality rate trends among Crohn’s disease and ulcerative colitis decedents stratified by race/ethnicity from 2006 to 2020. A-D: Trends in age-standardized mortality rate (ASMR) per 100000 persons are shown among Hispanic Crohn’s disease (CD) decedents (A), non-Hispanic white CD decedents (B), non-Hispanic black CD decedents (C), Hispanic ulcerative colitis (UC) decedents (D), non-Hispanic white UC decedents (E), and non-Hispanic black UC decedents (F). Error bars represent the 95% confidence intervals for predicted ASMR. ASMR: Age-standardized mortality rate; COVID-19: Coronavirus disease 2019.

Figure 4 Observed coronavirus disease 2019-related, non-coronavirus disease 2019-related, and predicted age-standardized mortality rate trends among inflammatory bowel disease decedents by place of death from 2006 to 2021. A-D: Trends in age-standardized mortality rate (ASMR) per 100000 persons are shown among inflammatory bowel disease decedents according to the place of death: At home or on arrival (A), medical facility (B), nursing home (C), and hospice facility (D). ¹Indicates observed value less than predicted value. Error bars represent the 95% confidence intervals for predicted ASMR. ASMR: Age-standardized mortality rate; COVID-19: Coronavirus disease 2019.

Figure 5 Age-standardized mortality rate trends among ulcerative colitis and Crohn’s disease decedents by top three causes of death from 2006 to 2021. A and B: Trends in age-standardized mortality rate per 100000 persons are shown among the top three causes of death of Crohn’s disease decedents (A) and ulcerative colitis decedents (B). ASMR: Age-standardized mortality rate.