Retrospective Study
Copyright ©The Author(s) 2024.
World J Gastroenterol. Apr 28, 2024; 30(16): 2233-2248
Published online Apr 28, 2024. doi: 10.3748/wjg.v30.i16.2233
Figure 1
Figure 1 Flowchart of participant selection. nCRT: Neoadjuvant chemoradiotherapy; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; MRI: Magnetic resonance imaging; PNI: Perineural invasion.
Figure 2
Figure 2 Radiomics workflow.
Figure 3
Figure 3 The process of feature selection and dimensionality reduction through least absolute shrinkage and selection operator. A-C: The process of 10-fold crossvalidation penalty parameter λ selection, according to the rule of the simplest model. The abscissa corresponding to the lowest point of model deviation is the optimal λ; D-F: Each colored line in the variation curve of the characteristic coefficient with value of λ, which was used to determine the non-zero coefficient characteristic parameters based on λ obtained in the upper panel of the figure. T2WI: T2-weighted imaging; T1CE: contrast-enhanced T1WI.
Figure 4
Figure 4 Receiver operating characteristic curves for perineural invasion prediction of different models. A: Receiver operating characteristic (ROC) curves in the training group; B: ROC curves in the internal validation group; C: ROC curves in the external validation group. CR: Clinical-radiomics predictive model; T2WI: T2-weighted imaging; T1CE: Contrast-enhanced T1WI.
Figure 5
Figure 5 Calibration curves of the clinical model, T2-weighted imaging + Contrast-enhanced T1WI fusion sequence radiomics model and clinical-radiomics prediction model. Diagonal lines serve as reference lines, representing the most suitable model. The clinical-radiomics prediction model shows optimal calibration. A: Calibration curves in the training group; B: Calibration curves in the internal validation group; C: Calibration curves in the external validation group. CR: Clinical-radiomics prediction model; T2WI: T2-weighted imaging; T1CE: Contrast-enhanced T1WI.
Figure 6
Figure 6 Decision curve analysis of the clinical model, T2-weighted imaging + contrast-enhanced T1WI fusion sequence radiomics model and clinical-radiomics prediction model. The clinical-radiomics prediction model exhibits the greatest net clinical benefit. A: Decision curve analysis (DCA) in the training group; B: DCA in the internal validation group; C: DCA in the external validation group. CR: Clinical-radiomics prediction model; T2WI: T2-weighted imaging; T1CE: Contrast-enhanced T1WI.
Figure 7
Figure 7 Concise nomogram was developed in the training group. cTNM: clinical TNM.
Figure 8
Figure 8 Online interactive dynamic web page nomogram based on the clinical-radiomics model was constructed to predict the perineural invasion status of patients. The Online tool is available at https://ly1070007554.shinyapps.io/dynnomapp/.