Establishment and application of an experimental model of human fetal hepatocytes for investigation of the protective effects of silybin and polyporus umbellalus polysaccharides

Figure 1 Normal human fetal hepatocytes. The cellular membrane is intact and microvilli can be clearly seen. × 7500

Figure 2 Normal human fetal hepatocytes. × 4500

Figure 3 Hepatocytes in the control group following exposure to CCl₄. The cellular membrane appears mesh-like. × 10500

Figure 4 Hepatocytes pretreated with silybin and exposed to CCl₄. The changes of the cellular membrane are similar to Figure 5. × 8000.

Figure 5 Hepatocytes pretreated with PSP and exposed to CCl₄. The cellular membrane is intact and microvilli swelling is present. × 7500

Figure 6 Hepatocytes in the non-pretreated control group after exposure to CCl₄. × 4500

Figure 7 Hepatocytes in the PSP pretreatment group. The ultrastructure is well preserved. × 4500

Figure 8 Hepatocytes in the silybin pretreatment group. The changes are similar to those in Figure 7. × 4500.