Tenofovir amibufenamide vs tenofovir alafenamide for treating chronic hepatitis B: A real-world study

Figure 1 Flow chart of the patient inclusion process. CHB: Chronic hepatitis B; TMF: Tenofovir amibufenamide; TAF: Tenofovir alafenamide.

Figure 2 Comparison of virological response rates between tenofovir amibufenamide and tenofovir alafenamide. A: Virological response (VR) rates of tenofovir amibufenamide (TMF) and tenofovir alafenamide (TAF) groups at 24 and 48 wk; B: VR rates of TMF and TAF groups at 24 and 48 wk with low-level viremia; C: VR rates of TMF and TAF groups at 24 and 48 wk with hepatitis B e antigen (HBeAg) negative; D: VR rates of TMF and TAF groups at 24 and 48 wk with HBeAg positive. TMF: Tenofovir amibufenamide; TAF: Tenofovir alafenamide; VR: Virological response; HBeAg: Hepatitis B e antigen.

Figure 3 Comparison of changes in hepatitis B virus DNA level, the ratios of alanine aminotransferase normalization and alanine aminotransferase level between the tenofovir amibufenamide and tenofovir alafenamide groups. A: Hepatitis B virus (HBV) DNA levels at baseline week, 24 wk and 48 wk in the tenofovir amibufenamide (TMF) and tenofovir alafenamide (TAF) groups; B: HBV-DNA reduction from 24 wk to 48 wk in the TMF and TAF groups; C: Alanine aminotransferase (ALT) normalization rate of TMF and TAF groups at 24 and 48 wk; D: ALT levels at baseline week, 24 wk and 48 wk in the TMF and TAF groups. TMF: Tenofovir amibufenamide; TAF: Tenofovir alafenamide; ALT: Alanine aminotransferase; HBV: Hepatitis B virus.

Figure 4 Comparison of the virological response rate and the alanine aminotransferase normalization rate between tenofovir amibufenamide and tenofovir alafenamide groups in patients with cirrhosis. A: Virological response rates of tenofovir amibufenamide (TMF) and tenofovir alafenamide (TAF) groups at 24 and 48 wk; B: Alanine aminotransferase normalization rate of TMF and TAF groups at 24 and 48 wk. TMF: Tenofovir amibufenamide; TAF: Tenofovir alafenamide; ALT: Alanine aminotransferase.