Clinical characteristics and outcome of autoimmune pancreatitis based on serum immunoglobulin G4 level: A single-center, retrospective cohort study

Figure 1 Flow diagram of the study design. A total of 308 patients were reviewed. Ninety-five patients were excluded due to other chief diagnoses (n = 20), insufficient data (n = 31), and non-fulfillment of the international consensus diagnostic criteria (n = 44). AIP: Autoimmune pancreatitis; ICDC: International consensus diagnostic criteria.

Figure 2 Cumulative relapse rates in the normal and abnormal groups. The cumulative relapse rates at 1 and 3 years were 3.8% and 11.0%, respectively, for the abnormal group and 2.0% and 6.9%, respectively, for the normal group (Log-Rank test, P = 0.023).

Figure 3 Univariate and multivariate Cox regression analysis for relapse of autoimmune pancreatitis. Univariate Cox regression analysis indicated that age (> 55 years), immunoglobulin (Ig)A (> 400 mg/dL), IgG4 (> 402 mg/dL), presence of thickened bile duct were risk factors of relapse of autoimmune pancreatitis. Multivariate Cox regression analysis identified three risk factors of relapse, including age (> 55 years), IgA (> 400 mg/dL) and IgG4 (> 402 mg/dL). ¹Others: Hepatic protectors, antibiotics and proton pump inhibitors. PLT: Hemoglobin; Ig: Immunoglobulin; ESR: Erythrocyte sedimentation rate; C3: Complement C3.