Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome

Figure 1 Patient flow. C: Constipation; D: Diarrhea; IBS: Irritable bowel syndrome; M: Mixed; U: “Unclassified” (subtype not determined).

Figure 2 Mean irritable bowel syndrome severity scoring system and Irritable bowel syndrome quality of life score at baseline and at the end of treatment by transit subtype. A: IBS-SSS; B: IBS-QOL. Error bars denote standard deviation. ^aP < 0.001 versus baseline. IBS: Irritable bowel syndrome; IBS-QOL: Irritable bowel syndrome quality of life; IBS-SSS: Irritable bowel syndrome severity scoring system; C: Constipation; D: Diarrhea; M: Mixed; NS: Not significant; U: Unclassified.

Figure 3 Irritable bowel syndrome quality of life score according to irritable bowel syndrome severity scoring system severity categories at baseline. IBS-QOL: Irritable bowel syndrome quality of life; IBS-SSS: Irritable bowel syndrome severity scoring system.

Figure 4 Mean irritable bowel syndrome severity scoring system and irritable bowel syndrome quality of life score at baseline and at the end of treatment. A: Mean irritable bowel syndrome severity scoring system score at baseline and at the end of treatment; B: Mean irritable bowel syndrome quality of life score at baseline and at the end of treatment. Error bars denote standard deviation. ^aP < 0.001 vs baseline. IBS-QOL: Irritable bowel syndrome quality of life; IBS-SSS: Irritable bowel syndrome severity scoring system.

Figure 5 Irritable bowel syndrome severity scoring system scores by domain at baseline and after treatment with B. longum 35624. ^aP < 0.001 vs baseline. IBS-SSS: Irritable bowel syndrome severity scoring system.

Figure 6 Change in the number of patients in different irritable bowel syndrome severity scoring system severity categories from baseline to after treatment with B. longum 35624. A: Number and percentage of patients by Irritable bowel syndrome severity scoring system (IBS-SSS) severity category at baseline (arrows indicate movement from one category to another one after 30 d of treatment with B. longum 35624); B: Number and percentage of patients by IBS-SSS severity category after 30 d of treatment with B. longum 35624. IBS-SSS: Irritable bowel syndrome severity scoring system.

Figure 7 Stool consistency by Bristol stool scale score recorded at baseline and every 10 d over 30 d in IBS-C, IBS-D, IBS-M, and IBS-U. C: Constipation; D: Diarrhea; IBS: Irritable bowel syndrome; M: Mixed; U: “Unclassified” (subtype not determined). A: IBS-C; B: IBS-D; C: IBS-M; D: IBS-U.