Role of intestinal flora in primary sclerosing cholangitis and its potential therapeutic value

doi:10.3748/wjg.v28.i44.6213

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Nov 28, 2022 (publication date) through Dec 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2022; 28(44): 6213-6229
Published online Nov 28, 2022. doi: 10.3748/wjg.v28.i44.6213

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Figure 1 The effect of intestinal flora dysbiosis in patients with primary sclerosing cholangitis. Intestinal flora dysbiosis causes increased intestinal permeability, intestinal lymphocyte homing, and entry of bacteria and their metabolites (i.e. pathogen-associated molecular patterns) into the liver. It also impairs normal bile acid metabolism and promotes bile duct inflammation and fibrosis. PAMPs: Pathogen-associated molecular patterns. By Figdraw, www.figdraw.com.

Citation: Li ZJ, Gou HZ, Zhang YL, Song XJ, Zhang L. Role of intestinal flora in primary sclerosing cholangitis and its potential therapeutic value. World J Gastroenterol 2022; 28(44): 6213-6229
URL: https://www.wjgnet.com/1007-9327/full/v28/i44/6213.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i44.6213