MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers

Figure 1 Volcano plot and heat map of the patients. A: Volcano plot of the 754-microRNA (miRNA) analyzed in inflammatory bowel disease patients. Control group: Crohn’s disease (CD). Threshold x: fold change = 1; Threshold y: P ≤ 0.05; B: Heat map of the 13 significantly different miRNA between the CD and ulcerative colitis patients with a fold-change in expression level greater than 1 relatively to the expression levels in CD patients (8 upregulated and 5 downregulated). miRNA: MicroRNA.

Figure 2 Overlap between predicted microRNA targets for microRNA differentially expressed and ulcerative colitis and Crohn’s disease susceptibility genes. Detailed information is provided in Supplementary material 1. miRNA: MicroRNA; UC: Ulcerative colitis; CD: Crohn’s disease.