Natural products that target macrophages in treating non-alcoholic steatohepatitis

Figure 1 Natural products that target macrophages for nonalcoholic steatohepatitis treatment. Both resident Kupffer cells and recruited macrophages are involved in the pathogenesis of nonalcoholic steatohepatitis. Modulation of macrophage activation, polarization, and recruitment by natural products contributes to nonalcoholic steatohepatitis improvement. Metabolic status affects the function of macrophages, and natural products also regulate macrophage metabolism. KC: Kupffer cell; MΦ: Macrophage; OXPHOS: Mitochondrial oxidative phosphorylation; IL: Interleukin; TNF: Tumor necrosis factor; CCR2: C-C motif receptor 2; MCP: Monocyte chemotactic protein.