Integrated network analysis of transcriptomic and protein-protein interaction data in taurine-treated hepatic stellate cells

Figure 1 Kyoto encyclopedia of genes and genomes pathway analysis of the differentially expressed genes. The color represents different pathways. The larger area represents more DEGs enriched in the pathway. DEGs: Differentially expressed genes; cMAP: Cyclic adenosine monophosphate; MAPK: Mitogen-activated protein kinase; PPAR: Peroxisome proliferator-activated receptor.

Figure 2 Heatmap of enriched terms across the differentially expressed genes, colored by P-values. MAPK: Mitogen-activated protein kinase.

Figure 3 Protein-protein interaction network of differentially expressed genes in taurine-treated hepatic stellate cell samples. The nearer the center, the higher the degrees; red coloring represents up-regulated genes; green coloring represents down-regulated genes; purple coloring represents genes from database; the shade is related to the change fold (darker colors indicate more apparent differences).

Figure 4 Functional sub-modules in the protein-protein interaction network of differentially expressed genes in the taurine-treated hepatic stellate cells. Red coloring represents up-regulated genes; green coloring represents down-regulated genes; purple coloring represents genes from database; the shade is related to the change fold (darker colors indicate more apparent differences).