Diagnostic and prognostic value of lncRNA cancer susceptibility candidate 9 in hepatocellular carcinoma

Figure 1 Cancer susceptibility candidate 9 expression and survival from TCGA database. A: Cancer susceptibility candidate 9 (CASC9) was highly expressed in cancer patients; B: The survival rate of the high CASC9 expression group was lower than that of the low CASC9 expression group (P = 0.011). ^bP < 0.01. CASC9: Cancer susceptibility candidate 9.

Figure 2 Cancer susceptibility candidate 9 expression in patients, its relationship with tumor size, Tumor, Node, Metastasis staging, lymph node metastasis, differentiation, and alpha fetoprotein expression, and its diagnostic value. A: Cancer susceptibility candidate 9 (CASC9) was highly expressed in the patient group, and the AUC was 0.933; B: Relationship between CASC9 expression and tumor size. The AUC was 0.726; C: Relationship between CASC9 expression and TNM staging. The AUC was 0.743; D: Relationship between CASC9 expression and lymph node metastasis. The AUC was 0.752; E: Relationship between CASC9 expression and differentiation. The AUC was 0.777; F: Relationship between CASC9 expression and AFP. The AUC was 0.738. ^bP < 0.01. CASC9: Cancer susceptibility candidate 9; AUC: area under the curve.

Figure 3 Relationship between cancer susceptibility candidate 9 and patients’ survival. A: The overall survival of patients; B: The 1-year survival of patients in the high and low Cancer susceptibility candidate 9 (CASC9) expression groups (P = 0.049); C: The 3-year survival of patients in the high and low CASC9 expression groups (P = 0.041); D: The 5-year survival of patients in the high and low CASC9 expression groups (P = 0.004). CASC9: Cancer susceptibility candidate 9.

Figure 4 Relationship between tumor, node, metastasis staging, lymph node metastasis, differentiation, alpha fetoprotein and 5-year survival of patients. A: The 5-year survival rate of stage I+II patients was higher than that of stage III+IV patients (P = 0.001); B: The 5-year survival rate of patients without lymph node metastasis was higher than that of patients with lymph node metastasis (^cP < 0.001); C: The 5-year survival rate of patients with moderate/high differentiation was higher than that of patients with low differentiation (P = 0.020); D: The 5-year survival rate of patients with AFP ≤ 200 was higher than that of patients with AFP > 200 (P = 0.001).