Basic Study
Copyright ©The Author(s) 2019.
World J Gastroenterol. Oct 21, 2019; 25(39): 5953-5960
Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.5953
Figure 1
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Figure 1 Portal pressure of the four male groups. Administration of CCl4 induced significant increase in portal pressure; however, no difference was found among SO PHT, and ORX PHT rats (15.2 ± 2.1 vs 16.7 ± 2.7 mmHg, P > 0.05). aP < 0.05 vs SO control rats; cP < 0.05 vs ORX control rats. PHT: Portal hypertension; SO: Sham operation; ORX: Orchiectomy.
Figure 2
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Figure 2 Portal pressure of the four female groups. Administration of CCl4 induced significant PHT; however, the portal pressure in SO PHT rats was lower than that in OVX PHT rats (12.7 ± 2.7 vs 16.5 ± 2.4 mmHg, P < 0.05). aP < 0.05 vs SO control rats; cP < 0.05 vs OVX control rats; eP < 0.05 vs SO PHT rats. PHT: Portal hypertension; SO: Sham operation; OVX: Ovariectomized.
Figure 3
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Figure 3 Concentration response curves of mesenteric arterioles to NE from the four male groups. In non-PHT male rats, cumulative NE concentration response curve of mesenteric arterioles in ORX control rats was shifted to the right compared to SO control rats. In PHT rats, the concentration response curves were shifted to the right, compared to those in non-PHT integral male rats. However, there was no difference between SO and ORX male rats with PHT. aP < 0.05 vs SO control rats; cP < 0.05 vs ORX control rats. PHT: Portal hypertension; SO: Sham operation; ORX: Orchiectomy.
Figure 4
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Figure 4 Concentration response curves of mesenteric arterioles to NE from the four female groups. In non-PHT female rats, concentration response curves coincided with each other in SO control and OVX control rats. In the PHT rats, the concentration response curves were lowered and shifted to the right compared to SO control rats. However, the concentration response curve was lowered and shifted to the right in OVX PHT rats compared to SO PHT rats. aP < 0.05 vs SO control rats; cP < 0.05 vs OVX control rats; eP < 0.05 vs SO PHT rats. PHT: Portal hypertension; SO: Sham operation; OVX: Ovariectomized.