Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke

Figure 1 Patient selection. CRC: Colorectal cancer.

Figure 2 Typical presentation of ischemic stroke in a colorectal cancer patient without conventional stroke mechanism. A 47-year-old male patient experienced acute ischemic stroke in the first 3 mo after diagnosis of colorectal cancer. Diffusion-weighted magnetic resonance imaging showed high signal changes in the middle cerebral and anterior cerebral and anterior choroidal arteries. Echocardiography results were normal.

Figure 3 Receiver operator characteristic curve analysis of the product of D-dimer, carcinoembryonic antigen, and neutrophil count. The area under the curve of the products was 0.889 ± 0.022 (95%CI: 0.847-0.932, P < 0.001). The optimum cut-off point was 252.06. At this cut-off value, the sensitivity was 86.0% and the specificity was 79.8%. CI: Confidence interval; ROC: Receiver operator characteristic.