Second primary malignancy risk after radiotherapy in rectal cancer survivors

Figure 1 Study inclusion flowchart. HIV: Human immunodeficiency virus; SPM: Second primary malignancy.

Figure 2 Competing-risk model plot for cumulative incidence of death and secondary primary malignancy, stratified by with/without radiotherapy. SPM: Secondary primary malignancy; RT: Radiotherapy.

Figure 3 Secondary cancer site analysis for (A) with/without radiotherapy, and (B) preoperative and postoperative radiotherapy. Referenced by surgery-alone group, ^aP < 0.05; HR: Hazard ratio; NA: Not applicable.